CAJ | 학술논문

微核(micronuclei,MN),也叫卫星核,是真核生物细胞中的一种异常结构,是基因组不稳定在细胞中的一种表现形式,根据其内容物成分来源分为“染色体型微核”和染色体外元件形成的微核,即“双微体型微核”,这两种形式微核在同一细胞中是独立产生和存在的.双微体是在肿瘤细胞中常见的染色体外元件,因此,了解双微体型微核产生的分子机制将有助于更清楚这些染色体外结构是如何保留在细胞内或者排出细胞外的.该文就双微体型微核产生的分子机制及微核的生物学活性作一综述.
미핵(micronuclei,MN),야규위성핵,시진핵생물세포중적일충이상결구,시기인조불은정재세포중적일충표현형식,근거기내용물성분래원분위“염색체형미핵”화염색체외원건형성적미핵,즉“쌍미체형미핵”,저량충형식미핵재동일세포중시독립산생화존재적.쌍미체시재종류세포중상견적염색체외원건,인차,료해쌍미체형미핵산생적분자궤제장유조우경청초저사염색체외결구시여하보류재세포내혹자배출세포외적.해문취쌍미체형미핵산생적분자궤제급미핵적생물학활성작일종술.
Micronuclei (MN) is also called satellite micronuclei.It is an abnormal structure in eukaryotic cells and a manifestation of genomic instability.MN can be divided into chromosome-type micronuclei and double minute-type micronuclei based on the contents of it.These two types of micronuclei exist and arise independently in a cell.A double minute (DM)is an extrachromosomal element that is commonly seen in tumor cells.Therefore,studying the biology of DM-type micronuclei will enable us to understand how these extrachromosomal structures may be retained within a cell or expelled from the cell.Here we summarize the molecular mechanism and the biology of DM-type micronuclei.