国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2013年
5期
201-205
,共5页
葡萄糖调节蛋白75%蛋白功能%肿瘤
葡萄糖調節蛋白75%蛋白功能%腫瘤
포도당조절단백75%단백공능%종류
Glucose-regulated protein 75 (GRP75)%Protein functions%Tumor
GRP75在细胞中参与多个细胞信号途径调节细胞应激反应、促进细胞增殖、抑制细胞凋亡.近年来,GRP75在多种肿瘤组织中高表达,并且与多种肿瘤的发生及转移等都有着密切的关联.因此,对GRP75功能的研究可为肿瘤的治疗提供了新的靶点.现就GRP75蛋白的相关功能及与肿瘤之间关系的研究现状展开综述.
GRP75在細胞中參與多箇細胞信號途徑調節細胞應激反應、促進細胞增殖、抑製細胞凋亡.近年來,GRP75在多種腫瘤組織中高錶達,併且與多種腫瘤的髮生及轉移等都有著密切的關聯.因此,對GRP75功能的研究可為腫瘤的治療提供瞭新的靶點.現就GRP75蛋白的相關功能及與腫瘤之間關繫的研究現狀展開綜述.
GRP75재세포중삼여다개세포신호도경조절세포응격반응、촉진세포증식、억제세포조망.근년래,GRP75재다충종류조직중고표체,병차여다충종류적발생급전이등도유착밀절적관련.인차,대GRP75공능적연구가위종류적치료제공료신적파점.현취GRP75단백적상관공능급여종류지간관계적연구현상전개종술.
GRP75 is implicated in multiple cellular signal transduction pathways regulating stress response,promoting cell proliferation,and inhibiting apoptosis.Recently,several studies reported that GRP75 protein is frequently overexpressed in many tumors.Moreover,elevated expression of GRP75 protein in tumor tissues is associated with tumorigenesis and metastases.Therefore,GRP75 is a novel therapeutic target for cancer treatment.This study aims to summarize the relationship between GRP75 and tumor.
