CAJ | 학술논문

钙敏感受体(CaSR)是G蛋白偶联的受体C家族成员之一,对机体维持钙稳态、保持正常生理功能起到关键作用.文章对CaSR的生物学特征、功能、信号转导及相关疾病进行了概述.重点阐述了CaSR在中枢神经系统的研究进展,其中包括脑内分布、功能以及与癫痫、阿尔茨海默病等中枢神经系统疾病关系,最后对其在中枢神经系统的研究前景进行了展望.
개민감수체(CaSR)시G단백우련적수체C가족성원지일,대궤체유지개은태、보지정상생리공능기도관건작용.문장대CaSR적생물학특정、공능、신호전도급상관질병진행료개술.중점천술료CaSR재중추신경계통적연구진전,기중포괄뇌내분포、공능이급여전간、아이자해묵병등중추신경계통질병관계,최후대기재중추신경계통적연구전경진행료전망.
The calcium-sensing receptor (CaSR) is a member of the family of G protein coupled receptors,which plays a critical role in maitanace of calcium homeostasis to keep normal physiological functions.The article provided a summary of biological features,functions,signal transduction and related diseases of CaSR,especially the involvement of CaSR in central nervous system (CNS).The distribution and functions of CaSR in brain and the role of CaSR in Alzheimer disease,epilepsy and other central system diseases were reviewed.In addition,the research perspective of CaSR was anticipated.