CAJ | 학술논문

内质网氨肽酶1(ERAPl)及其异构体内质网氨肽酶2(ERAP2)都属于锌指金属基质肽酶M1家族中的“催产素酶亚家族”,共用GAMEN和HEXXH(X)18E锌结合基序.ERAPs在细胞内质网中参与内源性抗原肽的修饰及提呈,被认为是内质网中参与内源性抗原肽修饰的关键酶.近年来GWAS研究显示ERAPs与自身免疫性疾病相关,本文对ERAPs结构、功能及其相关疾病进行综述.
내질망안태매1(ERAPl)급기이구체내질망안태매2(ERAP2)도속우자지금속기질태매M1가족중적“최산소매아가족”,공용GAMEN화HEXXH(X)18E자결합기서.ERAPs재세포내질망중삼여내원성항원태적수식급제정,피인위시내질망중삼여내원성항원태수식적관건매.근년래GWAS연구현시ERAPs여자신면역성질병상관,본문대ERAPs결구、공능급기상관질병진행종술.
The ER aminopeptidase 1 (ERAP1) and the closely related ER aminopeptidase ERAP2,belong to the M1 family of zinc-metallopeptidase enzymes which share the consensus GAMEN and HEXXH (X) 18 E zincbinding motifs essential for enzymatic activity.ERAPs involved in endogenous antigen peptide processing and presentation in endoplasmic reticulum and was considered as key enzyme in endogenous peptides modification.Recent GWAS showed the association of ERAP1 and ERAP2 with several autoimmune diseases.In this review,we provide a general overview of ERAP1 and ERAP2 genes,their biological functions and their relevancy in related disease.