CAJ | 학술논문

Wip1(PPM1D)是PP2C磷酸酶家族的一员,并且是一种罕有的致癌的丝/苏氨酸磷酸酶.在细胞损伤修复过程中,Wip1起着重要的作用.实验表明作为DNA损伤应答通路的调控因子,Wip1有去磷酸化P53,ATM等抑癌基因的作用.同时,P53信号通路也是造成Wip1具有致癌性的一个重要组成部分.
Wip1(PPM1D)시PP2C린산매가족적일원,병차시일충한유적치암적사/소안산린산매.재세포손상수복과정중,Wip1기착중요적작용.실험표명작위DNA손상응답통로적조공인자,Wip1유거린산화P53,ATM등억암기인적작용.동시,P53신호통로야시조성Wip1구유치암성적일개중요조성부분.
The Wild-type P53-induced phosphatase 1,Wip1 (or PPM1D),is a member of the type 2C phosphatases,which is an unusual serine/threonine phosphatase with oncogenic activity.Wip1 plays an important role in DNA damage-induced networks.Wip1 acts as a regulator of the DNA damage response by dephosphorylating multiple tumor suppressors,including P53,ATM et al.And,the suppression of P53 signaling pathways by Wip1 are important components of its oncogenicity.