CAJ | 학술논문

目的应用Meta分析探讨中国汉族人群ApoE基因多态性与冠心病易感性的关联.方法对入选文献的基因型进行哈代-温伯格遗传平衡检验.根据异质性检验结果选用固定或随机效应模型.采用RevMan 5.1和Stata 1 1.0软件进行Meta分析.结果共纳入符合条件的文献25篇,纳入文献无明显发表偏倚.以基因型ε3/3为参照,ε2/2+ε2/3合并统计量OR(95％ CI)为1.10(0.93,1.30),P=0.25,无统计学意义;ε3/4+ε4/4合并统计量OR(95％CI)为2.03(1.66,2.48),P=0.00,与冠心病相关;以等位基因ε3为参照,ε2 vs ε3 OR(95％ CI)为1.10(0.95,1.27),P=0.21,无统计学意义;ε4 vs ε3 OR(95％ CI)为1.95(1.71,2.23),P=0.00,与冠心病相关.结论载脂蛋白ε2/2+ε2/3及ε2与冠心病无显著关联,而ε4/4+ε4/3及ε4可能是冠心病的危险因素.
목적 응용Meta분석탐토중국한족인군ApoE기인다태성여관심병역감성적관련.방법 대입선문헌적기인형진행합대-온백격유전평형검험.근거이질성검험결과선용고정혹수궤효응모형.채용RevMan 5.1화Stata 1 1.0연건진행Meta분석.결과 공납입부합조건적문헌25편,납입문헌무명현발표편의.이기인형ε3/3위삼조,ε2/2+ε2/3합병통계량OR(95％ CI)위1.10(0.93,1.30),P=0.25,무통계학의의;ε3/4+ε4/4합병통계량OR(95％CI)위2.03(1.66,2.48),P=0.00,여관심병상관;이등위기인ε3위삼조,ε2 vs ε3 OR(95％ CI)위1.10(0.95,1.27),P=0.21,무통계학의의;ε4 vs ε3 OR(95％ CI)위1.95(1.71,2.23),P=0.00,여관심병상관.결론 재지단백ε2/2+ε2/3급ε2여관심병무현저관련,이ε4/4+ε4/3급ε4가능시관심병적위험인소.
Objective To evaluate the associations between gene polymorphisms in apolipoprotein E (ApoE) and coronary artery disease (CAD) in China Han population using the meta-analysis.Methods Hardy-Weinberg equilibrium (HWE) test was used to check genetic equilibrium among genotypes for the selected literature.A fixed or random effect model was used on the basis of heterogeneity.This meta-analysis was performed by Review Manager 5.1 and Stata 1 1.0 Software.Results Twenty-five reports met the inclusion criteria for this meta-analysis.Compared with the ε3/3 genotype,the pooled OR(95％CI) of ε2/2 +ε2/3 was 1.10(0.93,1.30),and P=0.25,with no statistical significant.The pooled OR(95％CI) of ε3/4 +ε4/4 was 2.03(1.66,2.48),and P =0.00,which were associated with CAD.Compared with the e3 allele,the ε2 had no statistical significant,with OR (95 ％ CI) =1.10 (0.95,1.27),P =0.21.However,the ε4 increased CAD risk,with OR (95 ％ CI) of 1.95(1..71,2.23),and P=0.00.Conclusion The ε2/2 +ε2/3 and ε2 were not associated with CAD.However,ε3/4 + ε4/4 vsε3/3 and ε4 might be the risk factors for CAD.