CAJ | 학술논문

Tau蛋白是一种微管相关性蛋白,在神经变性疾病中扮演着重要角色,尤其在阿尔茨海默病(AD)中,Tau蛋白的过度磷酸化被视为特征性的病理学表现.尽管过度磷酸化Tau蛋白能够导致线粒体功能障碍进而引起了相应的临床疾病,但其导致线粒体功能障碍的具体机制尚不明确,越来越多的学者认为Tau蛋白导致线粒体功能障碍并不是通过一个单一的过程,虽然在神经变性中的作用还存在一些争议,但是对Tau蛋白导致线粒体功能障碍的探讨可能对神经变性机制的研究提供重要的线索,该文主要就AD中Tau蛋白导致线粒体功能障碍的可能机制作一简单综述.
Tau단백시일충미관상관성단백,재신경변성질병중분연착중요각색,우기재아이자해묵병(AD)중,Tau단백적과도린산화피시위특정성적병이학표현.진관과도린산화Tau단백능구도치선립체공능장애진이인기료상응적림상질병,단기도치선립체공능장애적구체궤제상불명학,월래월다적학자인위Tau단백도치선립체공능장애병불시통과일개단일적과정,수연재신경변성중적작용환존재일사쟁의,단시대Tau단백도치선립체공능장애적탐토가능대신경변성궤제적연구제공중요적선색,해문주요취AD중Tau단백도치선립체공능장애적가능궤제작일간단종술.
Tau is a microtubule-associated protein,and plays an important role in neurodegenerative diseases.The hyperphosphorylationg of Tau protein is considered as a characteristic pathogenic change,especially in Alzheimer' s disease.Though the hyperphosphorylated Tau protein can lead to mitochondrial dysfunction followed by corresponding diseases,the mechanism of mitochondrial dysfunction caused by Tau protein is unclear.More and more researchers have attempted to confirm that the mitochondrial dysfunction caused by Tau protein is not a single process.The study of mitochondrial dysfunction caused by Tau protein may provide a better understanding on the mechanism of neurodegeneration with important clues,though the role in neurodegeneration still remain unclear.In this paper,we make a brief review about the research progress of mitochondrial dysfunction caused by tau protein in AD.