CAJ | 학술논문

细胞色素P450 (CYP) 4A和4F酶将花生四烯酸代谢生成二十羟基二十碳四烯酸(20-HETE),20-HETE一方面通过收缩外周血管起升高血压作用,另一方面,通过抑制水钠吸收起抗高血压作用.在高血压动物模型中发现20-HETE不仅仅与高血压密切相关,还发现20-HETE的变化伴随着血糖的异常,而后在糖尿病动物模型及人群中也证实了20-HETE的改变.该文就对20-HETE在血压、血糖调控方面作一综述.
세포색소P450 (CYP) 4A화4F매장화생사희산대사생성이십간기이십탄사희산(20-HETE),20-HETE일방면통과수축외주혈관기승고혈압작용,령일방면,통과억제수납흡수기항고혈압작용.재고혈압동물모형중발현20-HETE불부부여고혈압밀절상관,환발현20-HETE적변화반수착혈당적이상,이후재당뇨병동물모형급인군중야증실료20-HETE적개변.해문취대20-HETE재혈압、혈당조공방면작일종술.
The cytochrome P450 4A and 4F family catalyze the metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).20-HETE has two contradictory effects in the development of hypertension.One is prohypertension resulting from constriction of the small arteries.The other is anti-hypertension caused by inhibition of sodium reabsorption.In the animal modes of hypertension,they suggested that 20-HETE is not only closely associated with hypertension,but also accompanies with blood glucose abnormalities.Furthermore,the abnormal 20-HETE level was also found in some diabetic animal models and human affected with diabetes.In this paper,20-HETE on blood pressure and glucose regulation was reviewed.