国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2013年
4期
195-200
,共6页
肠道病毒属%疫苗,灭活%手足口病
腸道病毒屬%疫苗,滅活%手足口病
장도병독속%역묘,멸활%수족구병
Enterovirus%Vaccines,inactivated%Hand,foot and mouth disease
手足口病是一种威胁5岁以下儿童生命健康的传染病,近年来已在亚太地区造成了多次上百万患者发病的大规模暴发,仅在中国大陆,自2008年以来,每年发病人数就超过百万,死亡数百人.然而,由于肠道病毒71型(enterovirus 71,EV71)是导致重症和死亡病例的主要病原体,而其致病机制尚不清楚,目前尚无有效的治疗性药物,因此EV71疫苗研究成为迫切需要解决的问题.此文就EV71灭活疫苗研究进展进行综述.
手足口病是一種威脅5歲以下兒童生命健康的傳染病,近年來已在亞太地區造成瞭多次上百萬患者髮病的大規模暴髮,僅在中國大陸,自2008年以來,每年髮病人數就超過百萬,死亡數百人.然而,由于腸道病毒71型(enterovirus 71,EV71)是導緻重癥和死亡病例的主要病原體,而其緻病機製尚不清楚,目前尚無有效的治療性藥物,因此EV71疫苗研究成為迫切需要解決的問題.此文就EV71滅活疫苗研究進展進行綜述.
수족구병시일충위협5세이하인동생명건강적전염병,근년래이재아태지구조성료다차상백만환자발병적대규모폭발,부재중국대륙,자2008년이래,매년발병인수취초과백만,사망수백인.연이,유우장도병독71형(enterovirus 71,EV71)시도치중증화사망병례적주요병원체,이기치병궤제상불청초,목전상무유효적치료성약물,인차EV71역묘연구성위박절수요해결적문제.차문취EV71멸활역묘연구진전진행종술.
Hand-foot-and-mouth disease (HFMD) is a life-threatening infectious disease of children under 5 years old.In recent years,major outbreaks of HFMD caused by enterovirus 71 (EV71) have emerged in the Asia-Pacific region,and have resulted in millions of cases and hundreds of deaths each year in China since 2008.Because EV71 is one of the main pathogens of HFMD resulting in severe diseases and death,the pathogenesis of HFMD is still unclear,and no effective therapeutic drugs for EV71 infection are currently available,development of vaccines against EV71 is urgently needed.This review summarizes research progress of inactivated EV71 vaccines.
