国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2013年
6期
308-311,321
,共5页
奈瑟球菌,脑膜炎,血清B群%疫苗%细菌外膜蛋白质类
奈瑟毬菌,腦膜炎,血清B群%疫苗%細菌外膜蛋白質類
내슬구균,뇌막염,혈청B군%역묘%세균외막단백질류
Neisseria meningitidis,serogroup B%Vaccines%Bacterial outer membrane proteins
脑膜炎球菌(Neisseria meningitidis,Nm)感染可导致流行性脑脊髓膜炎和败血症,有较高的病死率.荚膜多糖及多糖结合疫苗能有效控制A、C、W135和Y群Nm感染,而对B群Nm (MenB)感染的预防,只有外膜囊泡疫苗在局部地区取得成功.目前,针对MenB疫苗的研究以外膜蛋白为基础.此文对MenB疫苗的研发进展及临床前研究中的几个关键评价指标进行综述.
腦膜炎毬菌(Neisseria meningitidis,Nm)感染可導緻流行性腦脊髓膜炎和敗血癥,有較高的病死率.莢膜多糖及多糖結閤疫苗能有效控製A、C、W135和Y群Nm感染,而對B群Nm (MenB)感染的預防,隻有外膜囊泡疫苗在跼部地區取得成功.目前,針對MenB疫苗的研究以外膜蛋白為基礎.此文對MenB疫苗的研髮進展及臨床前研究中的幾箇關鍵評價指標進行綜述.
뇌막염구균(Neisseria meningitidis,Nm)감염가도치류행성뇌척수막염화패혈증,유교고적병사솔.협막다당급다당결합역묘능유효공제A、C、W135화Y군Nm감염,이대B군Nm (MenB)감염적예방,지유외막낭포역묘재국부지구취득성공.목전,침대MenB역묘적연구이외막단백위기출.차문대MenB역묘적연발진전급림상전연구중적궤개관건평개지표진행종술.
Neisseria meningitidis (Nm) is a major cause of epidemic cerebrospinal meningitis and septicemia with high fatality rates.Effective polysaccharide vaccines and conjugate vaccines have been developed to control the infections caused by groups A,C,W135 and Y Nm,but there are no commonly used,effective vaccines against group B Nm (MenB) except that several outer membrane vesicles based vaccines are effective in certain areas.Current vaccine strategies are focused on outer membrane proteins.This paper reviews the progress in development of MenB vaccines and some key points of preclinical evaluation.
