国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2014年
4期
198-202
,共5页
HSP70热休克蛋白质类%肿瘤%未折叠蛋白反应%分子靶向治疗
HSP70熱休剋蛋白質類%腫瘤%未摺疊蛋白反應%分子靶嚮治療
HSP70열휴극단백질류%종류%미절첩단백반응%분자파향치료
HSP70 heat-shock proteins%Neoplasms%Unfolded protein response%Molecular targeted therapy
葡萄糖调节蛋白78(glucose regulated protein 78 kD,GRP78),属于热休克蛋白70家族中的一员,在正常细胞中低/不表达,而在多种恶性肿瘤细胞(肺癌、乳腺癌、结直肠癌、头颈癌、肝癌等)中呈高表达,提示GRP78与肿瘤的发生和发展密切相关,这在肿瘤治疗方面存在潜在的应用价值.此文对GRP78结构、GRP78与肿瘤发生发展的关系、基于GRP78的靶向治疗等方面进行了探讨.
葡萄糖調節蛋白78(glucose regulated protein 78 kD,GRP78),屬于熱休剋蛋白70傢族中的一員,在正常細胞中低/不錶達,而在多種噁性腫瘤細胞(肺癌、乳腺癌、結直腸癌、頭頸癌、肝癌等)中呈高錶達,提示GRP78與腫瘤的髮生和髮展密切相關,這在腫瘤治療方麵存在潛在的應用價值.此文對GRP78結構、GRP78與腫瘤髮生髮展的關繫、基于GRP78的靶嚮治療等方麵進行瞭探討.
포도당조절단백78(glucose regulated protein 78 kD,GRP78),속우열휴극단백70가족중적일원,재정상세포중저/불표체,이재다충악성종류세포(폐암、유선암、결직장암、두경암、간암등)중정고표체,제시GRP78여종류적발생화발전밀절상관,저재종류치료방면존재잠재적응용개치.차문대GRP78결구、GRP78여종류발생발전적관계、기우GRP78적파향치료등방면진행료탐토.
Glucose regulated protein 78 kD(GRP78) is a member of the heat shock protein 70 (HSP70) family.GRP78 has no/low expression on normal cells and over-expression on malignant tumor cells,suggesting that GRP78 is closely related to tumor occurrence and development and may have potential application in cancer therapy.This paper discusses the structure of GRP78,its relationship with tumor occurrence and development,targeted therapy based on GRP78,and so on.
