国际眼科纵览
國際眼科縱覽
국제안과종람
OREIGN MEDICAL SCIENCES
2012年
6期
379-382
,共4页
基质信号蛋白CCN1/Cyr61%新生血管形成%纤维化%糖尿病视网膜病变
基質信號蛋白CCN1/Cyr61%新生血管形成%纖維化%糖尿病視網膜病變
기질신호단백CCN1/Cyr61%신생혈관형성%섬유화%당뇨병시망막병변
CCN1/Cyr61%neovascularization%fibration%diabetic retinopathy
基质信号蛋白CCN1又名富半胱氨酸蛋白61(Cysteine rich 61,Cyr61),是基质蛋白(CCN)家族成员中第一个被克隆,由生长因子诱导产生的富含半胱氨酸的分泌性肝素连接蛋白.作为一种重要的细胞基质调节因子,CCN1/Cyr61在细胞黏附、增生、迁移、分化以及胚胎发育、血管生成、伤口修复、炎症反应、肿瘤的发生发展等生理病理过程中发挥了重要的作用.近年研究发现CCN1/Cyr61参与了视网膜病理性的血管新生、增生及纤维化过程,与糖尿病视网膜病变的发生发展密切相关.
基質信號蛋白CCN1又名富半胱氨痠蛋白61(Cysteine rich 61,Cyr61),是基質蛋白(CCN)傢族成員中第一箇被剋隆,由生長因子誘導產生的富含半胱氨痠的分泌性肝素連接蛋白.作為一種重要的細胞基質調節因子,CCN1/Cyr61在細胞黏附、增生、遷移、分化以及胚胎髮育、血管生成、傷口脩複、炎癥反應、腫瘤的髮生髮展等生理病理過程中髮揮瞭重要的作用.近年研究髮現CCN1/Cyr61參與瞭視網膜病理性的血管新生、增生及纖維化過程,與糖尿病視網膜病變的髮生髮展密切相關.
기질신호단백CCN1우명부반광안산단백61(Cysteine rich 61,Cyr61),시기질단백(CCN)가족성원중제일개피극륭,유생장인자유도산생적부함반광안산적분비성간소련접단백.작위일충중요적세포기질조절인자,CCN1/Cyr61재세포점부、증생、천이、분화이급배태발육、혈관생성、상구수복、염증반응、종류적발생발전등생리병리과정중발휘료중요적작용.근년연구발현CCN1/Cyr61삼여료시망막병이성적혈관신생、증생급섬유화과정,여당뇨병시망막병변적발생발전밀절상관.
The extracellular matrix-associated signaling protein CCN1,also named Cyr61,is the first cloned member of CCN family,which is identified as a secreted,cysterine-rich,heparin binding protein induced by growth factors.As an important regulator in extracellular matrix (ECM),it has been shown to mediate functions as diverse as cell adhesion,proliferation,migration,adhesion and differentiation.It also plays vital roles in many complex processes,such as angiogenesis,wound repair,inflammation and tumorigenesis.Resent studies have found that CCN1/Cyr61 involved in the process of neovascularization,proliferation and fibration of the retina and is correlated with the occurrence and development of diabetic retinopathy.
