CAJ | 학술논문

Alzheimer病(Alzheimer's disease,AD)是一种进行性神经变性疾病,它是导致老年痴呆的主要原因且至今无法治愈.β淀粉样蛋白斑块沉积和tau蛋白引起的神经纤维缠结是导致AD患者大脑病变的两大主要机制.近来发现越来越多的AD患者除了意识和行为障碍,还存在眼部症状.有研究表明AD相关的β淀粉样蛋白斑块不仅沉积于大脑,同时累及视网膜,且视网膜病变较大脑病变更易观察诊断.因此,研究AD相关的视网膜变性不仅有助于深入了解脑部病变过程,为AD提供一种全新的简单有效的诊疗方法,也有益于研究如青光眼和年龄相关性黄斑变性等其他视网膜变性类疾病的病理机制.
Alzheimer병(Alzheimer's disease,AD)시일충진행성신경변성질병,타시도치노년치태적주요원인차지금무법치유.β정분양단백반괴침적화tau단백인기적신경섬유전결시도치AD환자대뇌병변적량대주요궤제.근래발현월래월다적AD환자제료의식화행위장애,환존재안부증상.유연구표명AD상관적β정분양단백반괴불부침적우대뇌,동시루급시망막,차시망막병변교대뇌병변경역관찰진단.인차,연구AD상관적시망막변성불부유조우심입료해뇌부병변과정,위AD제공일충전신적간단유효적진료방법,야유익우연구여청광안화년령상관성황반변성등기타시망막변성류질병적병리궤제.
Alzheimer's disease (AD),a devastating neurodegenerative disease,is the primary cause of dementia with no cure available.Amyloid plaques and neurofibrillary tangles underlie the two pathological hallmarks in AD brain.In addition to cognitive and behavioral deficits,vision abnormalities are prevalent in AD patients.While most AD related pathology occurs in the brain,the disease has also been reported to affect the retina,which is more accessible for imaging than the brain.Therefore,studying AD-related retinal degeneration is a promising way for the investigation on AD pathologies and therapies that would eventually benefit the brain and cellular mechanisms in other retinal degenerations such as glaucoma and age-related macular degeneration.