国际眼科纵览
國際眼科縱覽
국제안과종람
OREIGN MEDICAL SCIENCES
2013年
5期
349-354
,共6页
视网膜神经节细胞%米诺环素%氧化应激%细胞凋亡%小胶质细胞
視網膜神經節細胞%米諾環素%氧化應激%細胞凋亡%小膠質細胞
시망막신경절세포%미낙배소%양화응격%세포조망%소효질세포
retinal ganglion cell%minocycline%oxidative stress%cell apoptosis%microglia
视网膜神经节细胞作为中枢神经系统的一部分,是青光眼和视网膜疾病的主要受损细胞.米诺环素是一种半合成的四环素类衍生物,除广谱抗菌功效外,还具有抗氧化、抗凋亡和抑制小胶质细胞活化的作用,对神经元具有一定的保护作用.研究证明米诺环素对视网膜神经节细胞也具有保护作用,在视神经外伤、青光眼和多种视网膜疾病的研究中均显示了不同程度的效果.本文就米诺环素对视网膜神经节细胞的神经保护作用及其作用机制作一综述.
視網膜神經節細胞作為中樞神經繫統的一部分,是青光眼和視網膜疾病的主要受損細胞.米諾環素是一種半閤成的四環素類衍生物,除廣譜抗菌功效外,還具有抗氧化、抗凋亡和抑製小膠質細胞活化的作用,對神經元具有一定的保護作用.研究證明米諾環素對視網膜神經節細胞也具有保護作用,在視神經外傷、青光眼和多種視網膜疾病的研究中均顯示瞭不同程度的效果.本文就米諾環素對視網膜神經節細胞的神經保護作用及其作用機製作一綜述.
시망막신경절세포작위중추신경계통적일부분,시청광안화시망막질병적주요수손세포.미낙배소시일충반합성적사배소류연생물,제엄보항균공효외,환구유항양화、항조망화억제소효질세포활화적작용,대신경원구유일정적보호작용.연구증명미낙배소대시망막신경절세포야구유보호작용,재시신경외상、청광안화다충시망막질병적연구중균현시료불동정도적효과.본문취미낙배소대시망막신경절세포적신경보호작용급기작용궤제작일종술.
Retinal ganglion cells(RGCs) is the mainly damaged cells in glaucoma and retinal diseases.As a part of central nervous system,RGCs death often leads to irreversible damage of visual function.Recently,neuroscience researchers focused on minocycline and its neuroprotective effect.Minocycline is a second-generation,semi-synthetic tetracycline.Besides its broad-spectrum antibacterial effect,minocycline was proved to have the ability to protect against neuron cell damage through mechanisms of anti-oxidation,anti-apoptosis,and inhibition the activation of microglia.More and more studies suggested that minocycline can also protect RGCs and has treatment potential in optic nerve injury,glaucoma,and various retinal diseases.This article reviews the neuroprotective effect of minocycline on RGCs and its mechanism.
