CAJ | 학술논문

真菌毒素(Mycotoxin)是由产毒真菌在适宜的环境条件下产生的具有毒性的次级代谢产物,主要毒性有致癌作用、遗传毒性、致畸作用、肝细胞毒性和免疫抑制等.真菌感染角膜后可能释放真菌毒素导致角膜损害,但至今对真菌毒素在真菌性角膜炎中究竟扮演什么角色,仍不明确.真菌毒素的生物合成受到一系列相关功能基因的调控;此外,pH值、碳氮比等环境条件也能影响其产量.本文就常见的真菌毒素的危害、调控因素及其可能在真菌性角膜炎发生发展中的作用进行综述.
진균독소(Mycotoxin)시유산독진균재괄의적배경조건하산생적구유독성적차급대사산물,주요독성유치암작용、유전독성、치기작용、간세포독성화면역억제등.진균감염각막후가능석방진균독소도치각막손해,단지금대진균독소재진균성각막염중구경분연십요각색,잉불명학.진균독소적생물합성수도일계렬상관공능기인적조공;차외,pH치、탄담비등배경조건야능영향기산량.본문취상견적진균독소적위해、조공인소급기가능재진균성각막염발생발전중적작용진행종술.
Mycotoxins are secondary metabolites produced by the toxigenic fungi in suitable environmental conditions,the main toxicity of which are carcinogenesis,genotoxicity,teratogenesis,hepatotoxicity and immunosuppression.After fungal infects the cornea,it may release mycotoxins to cause corneal damage.However what roles do the mycotoxins play in fungal keratitis is still unclear.The biosynthesis of mycotoxinis is regulated by a series of related function genes ; in addition,pH value,carbon nitrogen ratio and other environmental conditions are the influence factors as well.This article reviews the common harms,regulatory factors and their possible roles in the occurrence and development of keratomycosis.