CAJ | 학술논문

严重损伤后角膜的修复及角膜移植后的抗免疫排斥反应是角膜疾病治疗中的重点和难点.间充质干细胞可在特定环境下诱导分化为角膜上皮细胞、角膜基质细胞等细胞类型,或通过旁分泌作用抑制炎性反应及新生血管的生成,进而保护损伤组织,促进角膜修复.此外,间充质干细胞还具有抗炎和调节免疫的特性,使其在抗角膜移植排斥反应中发挥作用.
엄중손상후각막적수복급각막이식후적항면역배척반응시각막질병치료중적중점화난점.간충질간세포가재특정배경하유도분화위각막상피세포、각막기질세포등세포류형,혹통과방분비작용억제염성반응급신생혈관적생성,진이보호손상조직,촉진각막수복.차외,간충질간세포환구유항염화조절면역적특성,사기재항각막이식배척반응중발휘작용.
The corneal healing following severe wound and the immune rejection after keratoplasty are the key and difficult points in treatment of corneal diseases.Mesenchymal stem cells could differentiate into corneal epithelial cells,stromal cells and other cell types in cornea,as well as suppresse inflammation and angiogenesis in a paracrine manner.Hence the injury corneal tissue was protected and the healing of cornea was promoted.In addition,the mesenchymal stem cells have potent anti-inflammatory and immunomodulatory properties,which enable them to exert the therapeutic effects on corneal allograft rejection.