CAJ | 학술논문

眼部新生血管是多种眼病引发视力障碍的重要原因.骨髓来源细胞(bone marrow-derived cells,BMC)经动员、迁移、黏附和分化等步骤参与其中,受衰老、吸烟等危险因素影响,是一个复杂的需要精确调控的过程.目前,BMC参与眼部新生血管形成的分子机制已成为研究的热点和难点,阐明其中的机制对了解眼部新生血管发生及以BMC为靶点的临床疾病治疗探索具有重要意义.
안부신생혈관시다충안병인발시력장애적중요원인.골수래원세포(bone marrow-derived cells,BMC)경동원、천이、점부화분화등보취삼여기중,수쇠로、흡연등위험인소영향,시일개복잡적수요정학조공적과정.목전,BMC삼여안부신생혈관형성적분자궤제이성위연구적열점화난점,천명기중적궤제대료해안부신생혈관발생급이BMC위파점적림상질병치료탐색구유중요의의.
Ocular neovascularization is a significant contributor to visual impairment in many eye diseases.Bone marrow-derived cells (BMCs) play important roles in the development of ocular neovascularization,in which BMCs are believed to undergo the steps of mobilization,migration,adhesion and differentiation.This process is delicately regulated and affected by multiple factors,including aging,smoking,and so on.Now it has become a research hotspot to investigate the molecular mechanism of BMCs involved ocular neovascularization,which is imperative for further studies on pathogenesis of ocular neovascularization and treatment strategies using BMCs as targets.