国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2013年
2期
34-36
,共3页
邱建清%许玲%吕毅%杜绪强%周国军%胡蓬勃
邱建清%許玲%呂毅%杜緒彊%週國軍%鬍蓬勃
구건청%허령%려의%두서강%주국군%호봉발
急性百草枯中毒%血液灌流%血浆置换
急性百草枯中毒%血液灌流%血漿置換
급성백초고중독%혈액관류%혈장치환
Acute paraquat poisoning%Hemoperfusion%Plasma exchange
目的 探讨血液灌流联合血浆置换治疗急性百草枯中毒患者的临床疗效.方法 纳入我科2010年1月至2012年12月收治的急性百草枯中毒患者,进行病例回顾研究.将受试者分三组,常规治疗组(n=17,其中男9例,女7例)采用药物治疗,血液灌流组(n=45,其中男25例,女20例)采用药物治疗+血液灌流,血液灌流联合血浆置换组(n=50,其中男29例,女21例)采用药物治疗+血液灌流及血浆置换.观察各组患者治愈率、平均存活时间、血液中百草枯及丙二醛浓度变化.应用t检验和x2检验进行数据统计.结果 血液灌流组、血液灌流联合血浆置换组急性百草枯中毒治愈率高于常规治疗组(分别为31.1％、52.0％、17.6％),平均存活时间延长[分别为(7.7±1.6)、(13.8±3.7)、(3.2±0.8)d],血液中百草枯及丙二醛浓度明显降低,差异有统计学意义(均P＜ 0.05).另外,血液灌流联合血浆置换组治愈率较血液灌流组提高,平均存活时间延长,血液中百草枯及丙二醛浓度明显降低,差异有统计学意义(均P＜0.05).结论 血液灌流联合血浆置换治疗急性百草枯中毒效果显著.
目的 探討血液灌流聯閤血漿置換治療急性百草枯中毒患者的臨床療效.方法 納入我科2010年1月至2012年12月收治的急性百草枯中毒患者,進行病例迴顧研究.將受試者分三組,常規治療組(n=17,其中男9例,女7例)採用藥物治療,血液灌流組(n=45,其中男25例,女20例)採用藥物治療+血液灌流,血液灌流聯閤血漿置換組(n=50,其中男29例,女21例)採用藥物治療+血液灌流及血漿置換.觀察各組患者治愈率、平均存活時間、血液中百草枯及丙二醛濃度變化.應用t檢驗和x2檢驗進行數據統計.結果 血液灌流組、血液灌流聯閤血漿置換組急性百草枯中毒治愈率高于常規治療組(分彆為31.1％、52.0％、17.6％),平均存活時間延長[分彆為(7.7±1.6)、(13.8±3.7)、(3.2±0.8)d],血液中百草枯及丙二醛濃度明顯降低,差異有統計學意義(均P＜ 0.05).另外,血液灌流聯閤血漿置換組治愈率較血液灌流組提高,平均存活時間延長,血液中百草枯及丙二醛濃度明顯降低,差異有統計學意義(均P＜0.05).結論 血液灌流聯閤血漿置換治療急性百草枯中毒效果顯著.
목적 탐토혈액관류연합혈장치환치료급성백초고중독환자적림상료효.방법 납입아과2010년1월지2012년12월수치적급성백초고중독환자,진행병례회고연구.장수시자분삼조,상규치료조(n=17,기중남9례,녀7례)채용약물치료,혈액관류조(n=45,기중남25례,녀20례)채용약물치료+혈액관류,혈액관류연합혈장치환조(n=50,기중남29례,녀21례)채용약물치료+혈액관류급혈장치환.관찰각조환자치유솔、평균존활시간、혈액중백초고급병이철농도변화.응용t검험화x2검험진행수거통계.결과 혈액관류조、혈액관류연합혈장치환조급성백초고중독치유솔고우상규치료조(분별위31.1％、52.0％、17.6％),평균존활시간연장[분별위(7.7±1.6)、(13.8±3.7)、(3.2±0.8)d],혈액중백초고급병이철농도명현강저,차이유통계학의의(균P＜ 0.05).령외,혈액관류연합혈장치환조치유솔교혈액관류조제고,평균존활시간연장,혈액중백초고급병이철농도명현강저,차이유통계학의의(균P＜0.05).결론 혈액관류연합혈장치환치료급성백초고중독효과현저.
Objective To investigate the effects of hemoperfusion and plasma exchange in the treatment of acute paraquat poisoning.Methods One hundred and twelve adults who were treated for acute paraquat poisoning at the Emergency Department of our hospital during 2010 January and 2012 December were retrospectively studied.The participants were then assigned to three groups:the conventional therapy group was treated with medicine; the medication + blood perfusion group was treated with medication plus hemopeffusion; while the blood perfusion combined with plasma exchange group was treated with medication + blood perfusion plus plasma exchange.Cure rate,mean survival tine,drug concentration and inflammatory mediators were measured at baseline and after the intervention.Students t test and Chi-square test were used for data analysis.Results In comparison with the conventional therapy group,the hemoperfusion group and the blood perfusion combined with plasma exchange group showed statistically significant improvement in cure rate,mean survival time,paraquat in blood and inflammatory medium concentration (all P ＜ 0.05).In addition,hemopeffusion combined with plasma exchange group indicated better cure rate,mean survival time,paraquat in blood and inflammatory medium concentration than the hemoperfusion group (all P ＜ 0.05).Conclusion Hemoperfusion plus plasma exchange may have remarkable curative effect on acute paraquat poisoning.
