CAJ | 학술논문

目的探讨血液灌流与血浆置换串联治疗急性二氯丙醇中毒的临床效果.方法对我院2010年1月至2012年12月收治的56例急性二氯丙醇中毒患者进行病例回顾研究.受试者分为两组,常规治疗组[n=26,其中男15例,女11例,年龄(33±15)岁]采用药物治疗,血液灌流串联血浆置换组[n =30,其中男19例,女11例,年龄(36±16)岁]采用药物治疗+血液灌流串联血浆置换治疗.观察两组患者多器官功能障碍综合征发生率、肝功能衰竭发生率、死亡率及平均存活时间.采用t检验和x2检验进行数据统计.结果血液灌流串联血浆置换组多器官功能障碍综合征发生率(43.33％ vs 80.77％)、肝功能衰竭发生率(53.33％ vs 92.31％)以及死亡率(26.67％ vs 69.23％)较常规治疗组低,平均存活时间延长[(13.8±3.7)vs(3.2±0.8)d],差异具有统计学意义(均P＜ 0.05).结论血液灌流串联血浆置换治疗急性二氯丙醇中毒患者疗效显著.
목적 탐토혈액관류여혈장치환천련치료급성이록병순중독적림상효과.방법 대아원2010년1월지2012년12월수치적56례급성이록병순중독환자진행병례회고연구.수시자분위량조,상규치료조[n=26,기중남15례,녀11례,년령(33±15)세]채용약물치료,혈액관류천련혈장치환조[n =30,기중남19례,녀11례,년령(36±16)세]채용약물치료+혈액관류천련혈장치환치료.관찰량조환자다기관공능장애종합정발생솔、간공능쇠갈발생솔、사망솔급평균존활시간.채용t검험화x2검험진행수거통계.결과 혈액관류천련혈장치환조다기관공능장애종합정발생솔(43.33％ vs 80.77％)、간공능쇠갈발생솔(53.33％ vs 92.31％)이급사망솔(26.67％ vs 69.23％)교상규치료조저,평균존활시간연장[(13.8±3.7)vs(3.2±0.8)d],차이구유통계학의의(균P＜ 0.05).결론 혈액관류천련혈장치환치료급성이록병순중독환자료효현저.
Objective To investigate hemoperfusion and plasma exchange in the treatment of acute 1,3-dichloropropanol poisoning.Methods Fifty-six patients who were treated for 1,3-dichloropropanol poisoning during January 2010 and December 2012 were enrolled in this retrospective study.All the participants were assigned to the conventional treatmcnt group (n =26,male 15,female 11,mean age (33 ± 15) years old) and the blood perfusion + plasma replacement group (n =30,male 19,female 11,mean age (36 ± 16) years old).Incidence of multiple organ dysfunction syndrome (MODS) and liver failure incidence,mortality and survival time were compared between the two groups.Student's t test or x2 test was used for data analysis.Results The blood perfusion + plasma replacement group showed higher incidence of MODS (43.33 ％ vs 80.77 ％),higher incidence of hepatic failure (53.33 ％ vs 92.31％) and prolonged survival time ((13.8 ± 3.7) vs (3.2 ± 0.8) d) (all P ＜ 0.05).Conclusion Hemoperfusion with plasma exchange could effectively treat acute 1,3-dichloropropanol.