CAJ | 학술논문

目的观察足三里穴位注射黄芪注射液对肿瘤患者放化疗后白细胞减少及细胞免疫功能的影响.方法按随机数字表法将2010年3月至2011年8月湖北省襄阳市中心医院60例恶性肿瘤放化疗后的患者随机分为两组30例,治疗组采用足三里穴位注射黄芪注射液治疗,对照组口服利血生、维生素B4、鲨肝醇治疗.两组患者分别于治疗前后查外周血白细胞,并经直接免疫荧光染色法及流式细胞仪检测外周血T淋巴细胞总数及其亚群变化.结果 ①临床疗效:治疗组总有效率为77.5％,对照组为52.5％,两组总有效率比较,差异有统计学意义(x2=8.027,P＜0.05).②白细胞计数及外周血T淋巴细胞亚群比较,治疗组白细胞计数为(3.56～4.21)×109/L,对照组为(2.89～3.39)×109/L,两组比较差异有统计学意义(t=2.435,P＜0.05)；治疗组CD3+、CD4+、CD4+/CD8+[(62±1.63)％、(43±0.80)％、(1.48±0.23)]较同组治疗前[(48±1.25)％、(31±0.74)％、(0.93±0.12)]明显升高(P＜0.05或0.01),对照组治疗前后无明显改变(P＞0.05)；两组治疗后比较有显著性差异(P＜0.05或0.01).结论足三里穴位注射黄芪注射液可调节患者细胞免疫功能,治疗放化疗后白细胞减少症.
목적 관찰족삼리혈위주사황기주사액대종류환자방화료후백세포감소급세포면역공능적영향.방법 안수궤수자표법장2010년3월지2011년8월호북성양양시중심의원60례악성종류방화료후적환자수궤분위량조30례,치료조채용족삼리혈위주사황기주사액치료,대조조구복리혈생、유생소B4、사간순치료.량조환자분별우치료전후사외주혈백세포,병경직접면역형광염색법급류식세포의검측외주혈T림파세포총수급기아군변화.결과 ①림상료효:치료조총유효솔위77.5％,대조조위52.5％,량조총유효솔비교,차이유통계학의의(x2=8.027,P＜0.05).②백세포계수급외주혈T림파세포아군비교,치료조백세포계수위(3.56～4.21)×109/L,대조조위(2.89～3.39)×109/L,량조비교차이유통계학의의(t=2.435,P＜0.05)；치료조CD3+、CD4+、CD4+/CD8+[(62±1.63)％、(43±0.80)％、(1.48±0.23)]교동조치료전[(48±1.25)％、(31±0.74)％、(0.93±0.12)]명현승고(P＜0.05혹0.01),대조조치료전후무명현개변(P＞0.05)；량조치료후비교유현저성차이(P＜0.05혹0.01).결론 족삼리혈위주사황기주사액가조절환자세포면역공능,치료방화료후백세포감소증.
Objective To observe the effect of Zusanli acupoint injection of Astragalus Membranaceus Injection on patients with tumor leukopenia after radiotherapy and chemotherapy and its influence on cellular immune function.Methods According to clinical case of random table,60 cases of malignant tumor patients in Hubei province Xiangyang city hospital from March 2010 to August 2011 were randomly divided into two groups of 30 patients in each group.The treatment group was treated with Zusanli acupoint injection of Astragalus Injection therapy,while the control group was taken Leucogen,vitaminB4,batyl alcohol orally.Venous blood and peripheral white blood cell were taken in both groups before and after treatment.Direct immunofluorescence staining and flow cytometry were used for the detection of peripheral blood T lymphocyte total number and its subsets.Results ① clinical efficacy:Total effectiveness was 77.5％in the treatment group,and 52.5％ the control group,the difference was statistically significant between the two groups (x2=8.027,P＜0.05).Comparison of the white blood cell count and T lymphocyte subsets of peripheral blood:the white blood cell count was (3.56～4.21) × 109/L in the treatment group,and (2.89～3.39) × 109/in the control group,there was significant difference between two groups (t=2.435,P＜0.05); there was significant elevation of CD3 +,CD4+,CD4+/CD8 + [(62± 1.63) ％,(43 ± 0.80) ％,(1.48 ± 0.23) in the treatment group after the treatment comparing with (48± 1.25)％,(31 ± 0.74)％,(0.93± 0.12) before the treatment (P＜0.05 or 0.01),while there was no such changes in the control group.Conclusion Zusanli acupoint injection of Astragalus Injection may modulate the cellular immune function of patients with cancer.It is effective in the treatment of leukopenia after radiotherapy and chemotherapy.