国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
11期
997-999
,共3页
侯可强%何广云%丁宁%屈彩琴
侯可彊%何廣雲%丁寧%屈綵琴
후가강%하엄운%정저%굴채금
丹红颗粒%全血黏度%血浆黏度%RBC压积%活血化瘀
丹紅顆粒%全血黏度%血漿黏度%RBC壓積%活血化瘀
단홍과립%전혈점도%혈장점도%RBC압적%활혈화어
Danhong granule%Blood viscosity%Plasma viscosity%RBC hematocrit
目的 观察丹红颗粒对血瘀模型大鼠血液流变学的影响,进一步探讨其活血化瘀的作用机理.方法 选取SD大鼠60只,按随机数字法分正常对照组、模型对照组[予等容量0.5％羧甲基纤维素钠(CMC-Na)],丹红颗粒高剂量组(3g/kg)、丹红颗粒中剂量组(1.5 g/kg)、丹红颗粒低剂量组(0.75 g/kg)、复方丹参滴丸组(3 g/kg).各组均按1 ml/kg容积灌胃,1次/d,连续7d.于末次给药后,采用皮下注射大剂量肾上腺素加冰水冷浴法复制大鼠血瘀证模型,观察丹红颗粒对血瘀模型大鼠血液流变学的影响.结果 丹红颗粒高剂量组、复方丹参滴丸均可明显降低血瘀模型大鼠全血黏度值(高切、中切和低切值[丹红颗粒高剂量组分别为(5.69±0.16)mPa·s、(6.97±0.48) mPa ·s、(22.56±1.69)mPa ·s;复方丹参滴丸组分别为(5.71±0.24) mPa·s、(7.04±0.51) mPa·s、(22.63±1.64) mPa·s]；血浆黏度值丹红颗粒高剂量组为(1.43±0.03) mPa ·s,复方丹参滴丸组为(1.42±0.03)mPa ·s；RBC压积值丹红颗粒高剂量组为(0.42±0.027) L/L,复方丹参滴丸组为(0.41±0.032) L/L.丹红颗粒中剂量组可降低血瘀模型大鼠全血黏度高切(5.95±0.37) mPa·s、低切(23.45±1.57) mPa·s,降低血浆黏度值(1.47±0.02)mPa·s；RBC压积(0.48±0.029) L/L;丹红颗粒低剂量组对血瘀模型大鼠全血黏度高切(7.15±0.41) mPa·s、中切(7.86±0.36) mPa·s、低切(28.68±1.69) mPa·s、血浆黏度(1.67±0.03) mPa·s、RBC压积(0.50±0.033) L/L降低不明显.结论 丹红颗粒高、中剂量组可降低血瘀模型大鼠的全血黏度(高切、中切和低切)、血浆黏度和RBC压积.
目的 觀察丹紅顆粒對血瘀模型大鼠血液流變學的影響,進一步探討其活血化瘀的作用機理.方法 選取SD大鼠60隻,按隨機數字法分正常對照組、模型對照組[予等容量0.5％羧甲基纖維素鈉(CMC-Na)],丹紅顆粒高劑量組(3g/kg)、丹紅顆粒中劑量組(1.5 g/kg)、丹紅顆粒低劑量組(0.75 g/kg)、複方丹參滴汍組(3 g/kg).各組均按1 ml/kg容積灌胃,1次/d,連續7d.于末次給藥後,採用皮下註射大劑量腎上腺素加冰水冷浴法複製大鼠血瘀證模型,觀察丹紅顆粒對血瘀模型大鼠血液流變學的影響.結果 丹紅顆粒高劑量組、複方丹參滴汍均可明顯降低血瘀模型大鼠全血黏度值(高切、中切和低切值[丹紅顆粒高劑量組分彆為(5.69±0.16)mPa·s、(6.97±0.48) mPa ·s、(22.56±1.69)mPa ·s;複方丹參滴汍組分彆為(5.71±0.24) mPa·s、(7.04±0.51) mPa·s、(22.63±1.64) mPa·s]；血漿黏度值丹紅顆粒高劑量組為(1.43±0.03) mPa ·s,複方丹參滴汍組為(1.42±0.03)mPa ·s；RBC壓積值丹紅顆粒高劑量組為(0.42±0.027) L/L,複方丹參滴汍組為(0.41±0.032) L/L.丹紅顆粒中劑量組可降低血瘀模型大鼠全血黏度高切(5.95±0.37) mPa·s、低切(23.45±1.57) mPa·s,降低血漿黏度值(1.47±0.02)mPa·s；RBC壓積(0.48±0.029) L/L;丹紅顆粒低劑量組對血瘀模型大鼠全血黏度高切(7.15±0.41) mPa·s、中切(7.86±0.36) mPa·s、低切(28.68±1.69) mPa·s、血漿黏度(1.67±0.03) mPa·s、RBC壓積(0.50±0.033) L/L降低不明顯.結論 丹紅顆粒高、中劑量組可降低血瘀模型大鼠的全血黏度(高切、中切和低切)、血漿黏度和RBC壓積.
목적 관찰단홍과립대혈어모형대서혈액류변학적영향,진일보탐토기활혈화어적작용궤리.방법 선취SD대서60지,안수궤수자법분정상대조조、모형대조조[여등용량0.5％최갑기섬유소납(CMC-Na)],단홍과립고제량조(3g/kg)、단홍과립중제량조(1.5 g/kg)、단홍과립저제량조(0.75 g/kg)、복방단삼적환조(3 g/kg).각조균안1 ml/kg용적관위,1차/d,련속7d.우말차급약후,채용피하주사대제량신상선소가빙수랭욕법복제대서혈어증모형,관찰단홍과립대혈어모형대서혈액류변학적영향.결과 단홍과립고제량조、복방단삼적환균가명현강저혈어모형대서전혈점도치(고절、중절화저절치[단홍과립고제량조분별위(5.69±0.16)mPa·s、(6.97±0.48) mPa ·s、(22.56±1.69)mPa ·s;복방단삼적환조분별위(5.71±0.24) mPa·s、(7.04±0.51) mPa·s、(22.63±1.64) mPa·s]；혈장점도치단홍과립고제량조위(1.43±0.03) mPa ·s,복방단삼적환조위(1.42±0.03)mPa ·s；RBC압적치단홍과립고제량조위(0.42±0.027) L/L,복방단삼적환조위(0.41±0.032) L/L.단홍과립중제량조가강저혈어모형대서전혈점도고절(5.95±0.37) mPa·s、저절(23.45±1.57) mPa·s,강저혈장점도치(1.47±0.02)mPa·s；RBC압적(0.48±0.029) L/L;단홍과립저제량조대혈어모형대서전혈점도고절(7.15±0.41) mPa·s、중절(7.86±0.36) mPa·s、저절(28.68±1.69) mPa·s、혈장점도(1.67±0.03) mPa·s、RBC압적(0.50±0.033) L/L강저불명현.결론 단홍과립고、중제량조가강저혈어모형대서적전혈점도(고절、중절화저절)、혈장점도화RBC압적.
Objective To study the effects of Danhong Granule on blood rheology of blood stasis rats,and further to investigate the mechanism of promoting blood circulation and removing blood stasis.Methods 60 SD rats were selected and randomly divided into 6 groups,namely,normal control group,model group to the capacity of 0.5％ sodium carboxymethyl cellulose (CMC-Na),Danhong granules in high dose group (3 g/kg),Danhong granules dose group(1.5 g/kg),Danhong granules low dose group(0.75 g/kg),and compound Danshen dripping pill group(3 g/kg).Each group received gastric lavage at 1 ml/kg volume,1/d,for 7 days.After the last administration,the rat model of blood stasis was reproduced by subcutaneous injection of high dose epinephrine with ice water bath method.The effects of Danhong granules on blood rheology of blood stasis model rats were studied.Results Danhong granules in high dose group and compound Danshen dripping pills could reduce blood stasis model rats in blood viscosity (high shear,cut and low cut values were:Danhong granules in high dose group were(5.69±0.16)mPa·s,(6.97±0.48)mPa·s,(22.56±1.69) mPa·s; Compound Danshen Dropping Pill group (5.71 ± 0.24) mPa·s,(7.04 ± 0.51) mPa·s,(22.63 ± 1.64) mPa·s,plasma viscosity respectively:Danhong granules in high dose group were (1.43 ±0.03)mPa·s,compound Danshen dripping pill group(1.42±0.03)mPa·s,RBC (hematocrit value were:Danhong granules in high dose group were (0.42± 0.027) L/L,compound Danshen dripping pill group (0.41 ± 0.032) L/L; Danhong granules dose group could significantly lower the blood stasis model rats in blood viscosity (high,low cut)value (5.95 ± 0.37) mPa·s,(23.45 ± 1.57) mPa·s,plasma viscosity(1.47 ± 0.02)mPa·s and RBC hematocrit value (0.48 ± 0.029) L/L low dose group; Danhong granules low dose group could reduced blood stasis model rats obviously in blood viscosity (high shear,cut and low shear),plasma viscosity and hematocrit values of RBC [respectively:the whole blood viscosity in(7.15±0.41)mPa · s,(7.86±0.36)mPa · s,(28.68±1.69)mPa · s,(1.67±0.03)mPa · s,(0.50±0.033)L/L].Conclusion Danhong Granule can reduce the blood stasis model rats in blood viscosity (high shear,cut and low shear),plasma viscosity and hematocrit value of RBC,by activating blood circulation,removing blood stasis and improving blood rheology.
