国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2013年
3期
214-216
,共3页
奉镭%黄家遂%李艳霞%左素清
奉鐳%黃傢遂%李豔霞%左素清
봉뢰%황가수%리염하%좌소청
柴芍承气汤%胰腺炎%肠道微生态%肠黏膜损伤
柴芍承氣湯%胰腺炎%腸道微生態%腸黏膜損傷
시작승기탕%이선염%장도미생태%장점막손상
Chaishao Chengqi Decotion%Pancreatitis%Intestinal microbiota%Intestinal mucosal lesion
目的 观察柴芍承气汤调节重症急性胰腺炎(SAP)肠道菌群微生态平衡及对肠黏膜损伤的作用.方法 选择2010年至2011年四川省遂宁市中心医院感染管理科SAP患者46例,采用随机数字表法将患者随机分为两组.对照组给予常规治疗,治疗组加用柴芍承气汤,两组均连续治疗7d后检测患者血浆二胺氧化酶(DAO)、D-乳酸水平以及肠道菌群变化.结果 治疗后7d,治疗组血浆DAO水平为(4.65±0.82) U/ml,较对照组(5.66±2.17) U/ml明显下降(P＜0.05)；乳酸为(l0.65±5.24) mg/L,与同组治疗前(11.51±5.78) mg/L比较,差异无统计学意义(P＞0.05),但高于对照组的(5.42±2.13)mg/L,(P＜0.05)；治疗组肠道双歧杆菌、乳杆菌总数为(6.02±1.42) In/g、(7.21±2.02) In/g,高于治疗前的(3.74±1.71)In/g、(4.03±1.79) In/g (P＜0.05),肠道菌群比例接近正常,对照组仍存在一定程度的菌群紊乱.结论 柴芍承气汤具有减轻SAP肠黏膜损伤、调节肠道菌群微生态平衡、保护肠屏障功能的作用.
目的 觀察柴芍承氣湯調節重癥急性胰腺炎(SAP)腸道菌群微生態平衡及對腸黏膜損傷的作用.方法 選擇2010年至2011年四川省遂寧市中心醫院感染管理科SAP患者46例,採用隨機數字錶法將患者隨機分為兩組.對照組給予常規治療,治療組加用柴芍承氣湯,兩組均連續治療7d後檢測患者血漿二胺氧化酶(DAO)、D-乳痠水平以及腸道菌群變化.結果 治療後7d,治療組血漿DAO水平為(4.65±0.82) U/ml,較對照組(5.66±2.17) U/ml明顯下降(P＜0.05)；乳痠為(l0.65±5.24) mg/L,與同組治療前(11.51±5.78) mg/L比較,差異無統計學意義(P＞0.05),但高于對照組的(5.42±2.13)mg/L,(P＜0.05)；治療組腸道雙歧桿菌、乳桿菌總數為(6.02±1.42) In/g、(7.21±2.02) In/g,高于治療前的(3.74±1.71)In/g、(4.03±1.79) In/g (P＜0.05),腸道菌群比例接近正常,對照組仍存在一定程度的菌群紊亂.結論 柴芍承氣湯具有減輕SAP腸黏膜損傷、調節腸道菌群微生態平衡、保護腸屏障功能的作用.
목적 관찰시작승기탕조절중증급성이선염(SAP)장도균군미생태평형급대장점막손상적작용.방법 선택2010년지2011년사천성수저시중심의원감염관이과SAP환자46례,채용수궤수자표법장환자수궤분위량조.대조조급여상규치료,치료조가용시작승기탕,량조균련속치료7d후검측환자혈장이알양화매(DAO)、D-유산수평이급장도균군변화.결과 치료후7d,치료조혈장DAO수평위(4.65±0.82) U/ml,교대조조(5.66±2.17) U/ml명현하강(P＜0.05)；유산위(l0.65±5.24) mg/L,여동조치료전(11.51±5.78) mg/L비교,차이무통계학의의(P＞0.05),단고우대조조적(5.42±2.13)mg/L,(P＜0.05)；치료조장도쌍기간균、유간균총수위(6.02±1.42) In/g、(7.21±2.02) In/g,고우치료전적(3.74±1.71)In/g、(4.03±1.79) In/g (P＜0.05),장도균군비례접근정상,대조조잉존재일정정도적균군문란.결론 시작승기탕구유감경SAP장점막손상、조절장도균군미생태평형、보호장병장공능적작용.
Objective To investigate the effects of Chaishao Chengqi Decotion on intestinal microbiota and intestinal mucosal lesion in severe acute pancreatitis(SAP).Methods 46 Patients with SAP were randomized into two groups.Routine medical management was initiated in two groups.The treatment group received Chaishao Chengqi Decotion for 1 week.The plasma concentrations ofDiamine Oxidase (DAO),D-lactate were detected and changes of microflora were evaluated by bacterial culture.Results The levels of DAO in the treatment group (4.65 ±0.82)U/ml were significantly lower than those in the control group (5.66 ±2.17) U/ml (P ＜ 0.05) 7 days after treatment.The levels of D-lactate in the treatment group (10.65 ± 5.24)mg/L were significantly higher than those in the control group (5.42±2.13)mg/L (P＜0.05).Bacterial culture revealed that the amount of bifidobaterium (6.02± 1.42)In/g and lactobacilli (7.21 ± 2.02) In/g were significantly increased when compared to those before treatment (3.74± 1.71)In/g and (4.03 ± 1.79)In/g respectively,while there was imbalance of intestinal microflora to some extent in the control group.Conelusien Chaishao Chengqi Decotion exerted the protective effects on gut barrier function by alleviating the damage of intestinal mucosa and balancing the intestinal microbiota following severe acute pancreatitis.
