国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2013年
3期
217-220
,共4页
复方川芎颗粒%痛经%药效学
複方川芎顆粒%痛經%藥效學
복방천궁과립%통경%약효학
Compound Chuanxiong granules%Dysmenorrheal%Pharrnacodynamics
目的 对复方川芎颗粒进行药效学研究,为其治疗痛经提供依据.方法 通过大鼠在体子宫收缩试验、对子宫内膜PGF2α影响试验、缩宫素致小鼠扭体法、二甲苯致小鼠耳廓肿胀法、正常小鼠凝血时间试验,分别考察复方川芎颗粒对子宫收缩、抗炎、镇痛、凝血时间的影响.结果 与空白对照组相比,复方川芎颗粒高、中、低剂量组均可降低血清前列腺素E2(PGE2)水平,分别为(79.2±4.3) ng/L、(79.3±12.9) ng/L、(88.2±7.6) ng/L;抑制缩宫素致小鼠扭体次数,高、中、低剂量组的平均抑制率分别为39.4％、46.8％、24.8％.二甲苯引起的小鼠耳廓肿胀程度,肿胀率分别为(31.7±21.0)％、(35.6士33.7)％、(59.3±35.0)％,并可缩短正常小鼠全血凝血时间(41.1±9.7)s、(43.3±10.1)s、(50.5±10.8)s.结论 复方川芎颗粒在治疗痛经方面具有良好的应用价值.
目的 對複方川芎顆粒進行藥效學研究,為其治療痛經提供依據.方法 通過大鼠在體子宮收縮試驗、對子宮內膜PGF2α影響試驗、縮宮素緻小鼠扭體法、二甲苯緻小鼠耳廓腫脹法、正常小鼠凝血時間試驗,分彆攷察複方川芎顆粒對子宮收縮、抗炎、鎮痛、凝血時間的影響.結果 與空白對照組相比,複方川芎顆粒高、中、低劑量組均可降低血清前列腺素E2(PGE2)水平,分彆為(79.2±4.3) ng/L、(79.3±12.9) ng/L、(88.2±7.6) ng/L;抑製縮宮素緻小鼠扭體次數,高、中、低劑量組的平均抑製率分彆為39.4％、46.8％、24.8％.二甲苯引起的小鼠耳廓腫脹程度,腫脹率分彆為(31.7±21.0)％、(35.6士33.7)％、(59.3±35.0)％,併可縮短正常小鼠全血凝血時間(41.1±9.7)s、(43.3±10.1)s、(50.5±10.8)s.結論 複方川芎顆粒在治療痛經方麵具有良好的應用價值.
목적 대복방천궁과립진행약효학연구,위기치료통경제공의거.방법 통과대서재체자궁수축시험、대자궁내막PGF2α영향시험、축궁소치소서뉴체법、이갑분치소서이곽종창법、정상소서응혈시간시험,분별고찰복방천궁과립대자궁수축、항염、진통、응혈시간적영향.결과 여공백대조조상비,복방천궁과립고、중、저제량조균가강저혈청전렬선소E2(PGE2)수평,분별위(79.2±4.3) ng/L、(79.3±12.9) ng/L、(88.2±7.6) ng/L;억제축궁소치소서뉴체차수,고、중、저제량조적평균억제솔분별위39.4％、46.8％、24.8％.이갑분인기적소서이곽종창정도,종창솔분별위(31.7±21.0)％、(35.6사33.7)％、(59.3±35.0)％,병가축단정상소서전혈응혈시간(41.1±9.7)s、(43.3±10.1)s、(50.5±10.8)s.결론 복방천궁과립재치료통경방면구유량호적응용개치.
Objective To investigate the pharrnacodynamics of compound Chuanxiong granules in treating dysmenorrhea.Methods The effects of compound Chuanxiong granules on uterus contraction,anti-inflammatory,analgesia and hemostasis were researched by rat's uterine smooth muscle contraction test in vivo,the level of prostaglandins F2α effect test,mice torsion model induced by oxytocin test,mice auricle swelling model induced by dimethylbenzene test,and the coagulation time of mice test.Results Compared wAth the model control group,Chuanxiong granules may obviously inhibit smooth muscle constriction resulted from oxytocin (the average inhibition ratio in high-dose group,middle-dose group and low-dose group were 32.3％,27.2％,17.6％),decline the levels ofprostaglandins F2 [the value in high-dose group,middle-does group and low-dose group was (79.2±4.3)rig/L,(79.3 ±12.9) ng/L and (88.2±7.6) ng/L] inhibit twist times of mice (the value in high-dose group,middle-does group and low-dose group was 39.4％,46.8％,24.8％),inhibit the auricular swelling of mice caused by dimethylbenzene [the value in high-dose group,middle-does group and low-dose group were(31.7±21.0)％,(35.6±33.7)％,(59.3±35.0)％],and shorten the coagulation time [thevalue in high-dose group,middle-does group and low-dose group was(41.1±9.7)s,(43.3±10.1)s,(50.5±10.8)s respectively].Conclusion Compound Chuanxiong granules is a effective agent to relieve dysmenorrhea.
