国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2013年
11期
982-984
,共3页
中药预防%补阳还五汤%下肢深静脉血栓形成%低分子肝素钠%骨科大手术
中藥預防%補暘還五湯%下肢深靜脈血栓形成%低分子肝素鈉%骨科大手術
중약예방%보양환오탕%하지심정맥혈전형성%저분자간소납%골과대수술
Preventive medicine%Buyang-huanwu decoction%Deep vein thrombosis%Low molecular heparin%Major orthopedic surgery
目的 探讨中药补阳还五汤加味防治骨科大手术后下肢深静脉血栓形成(deep veinthrombosis,DVT)的疗效优劣及安全性.方法 筛选60例患者随机分两组,治疗组口服补阳还五汤加味汤,2次/d;对照组皮下注射低分子肝素钠5000IU,1次/d.术后第1、7、14天观察凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体(D-dimer)及下肢深静脉血管彩超变化及术后48 h伤口引流量测定.结果 ①DVT发生率比较:用药后第7天治疗组DVT发生率稍高于对照组,1周后两组发生率基本相当,治疗结束后治疗组DVT发生率为6.66％(2/30),对照组为10.0％(3/30),两组DVT发生率比较,差异有统计学意义(P＜0.05).②两组D-dimer变化比较:两组用药后第1天和第14天D-dimer[治疗组分别为(0.782±0.472) mg/1、(0.320±0.102) mg/1;对照组分别为(0.720±0.421) mg/1、(0.417±0.217) mg/1]与同组治疗前[治疗组为(0.548±0.245) mg/L；对照组为(0.560±0.195) mg/1]比较,用药后第1天D-dimer均较同组治疗前明显升高(P＜0.01),用药后第14天D-dimer均较同组治疗前降低,但差异无统计学意义(P＞0.05).结论 补阳还五汤加味在骨科大手术后初期疗效稍差于低分子肝素钠,但整体疗效及安全性优于对照组.
目的 探討中藥補暘還五湯加味防治骨科大手術後下肢深靜脈血栓形成(deep veinthrombosis,DVT)的療效優劣及安全性.方法 篩選60例患者隨機分兩組,治療組口服補暘還五湯加味湯,2次/d;對照組皮下註射低分子肝素鈉5000IU,1次/d.術後第1、7、14天觀察凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)、纖維蛋白原(FIB)和D-二聚體(D-dimer)及下肢深靜脈血管綵超變化及術後48 h傷口引流量測定.結果 ①DVT髮生率比較:用藥後第7天治療組DVT髮生率稍高于對照組,1週後兩組髮生率基本相噹,治療結束後治療組DVT髮生率為6.66％(2/30),對照組為10.0％(3/30),兩組DVT髮生率比較,差異有統計學意義(P＜0.05).②兩組D-dimer變化比較:兩組用藥後第1天和第14天D-dimer[治療組分彆為(0.782±0.472) mg/1、(0.320±0.102) mg/1;對照組分彆為(0.720±0.421) mg/1、(0.417±0.217) mg/1]與同組治療前[治療組為(0.548±0.245) mg/L；對照組為(0.560±0.195) mg/1]比較,用藥後第1天D-dimer均較同組治療前明顯升高(P＜0.01),用藥後第14天D-dimer均較同組治療前降低,但差異無統計學意義(P＞0.05).結論 補暘還五湯加味在骨科大手術後初期療效稍差于低分子肝素鈉,但整體療效及安全性優于對照組.
목적 탐토중약보양환오탕가미방치골과대수술후하지심정맥혈전형성(deep veinthrombosis,DVT)적료효우렬급안전성.방법 사선60례환자수궤분량조,치료조구복보양환오탕가미탕,2차/d;대조조피하주사저분자간소납5000IU,1차/d.술후제1、7、14천관찰응혈매원시간(PT)、활화부분응혈활매시간(APTT)、섬유단백원(FIB)화D-이취체(D-dimer)급하지심정맥혈관채초변화급술후48 h상구인류량측정.결과 ①DVT발생솔비교:용약후제7천치료조DVT발생솔초고우대조조,1주후량조발생솔기본상당,치료결속후치료조DVT발생솔위6.66％(2/30),대조조위10.0％(3/30),량조DVT발생솔비교,차이유통계학의의(P＜0.05).②량조D-dimer변화비교:량조용약후제1천화제14천D-dimer[치료조분별위(0.782±0.472) mg/1、(0.320±0.102) mg/1;대조조분별위(0.720±0.421) mg/1、(0.417±0.217) mg/1]여동조치료전[치료조위(0.548±0.245) mg/L；대조조위(0.560±0.195) mg/1]비교,용약후제1천D-dimer균교동조치료전명현승고(P＜0.01),용약후제14천D-dimer균교동조치료전강저,단차이무통계학의의(P＞0.05).결론 보양환오탕가미재골과대수술후초기료효초차우저분자간소납,단정체료효급안전성우우대조조.
Objective To discuss Buyang-huanwu decoction preventing the formation of lower limb deep vein thrombosis (DVT) after major orthopedic surgery.Methods 60 patients were randomly divided into a treatment group and a control group.The treatment group was treated with oral liquid of Buyang-huanwu,twice a day; while the control group was treated with 5000IU of low molecular heparin through subcutaneous injection,once daily.Prothrombin time (PT),activated partial thromboplatin time (APTT),fibrinogen (FIB),D-dimer,lower limb deep vein color B ultrasonic and the wound flow changes after 48 hours were observed at 1st,7th,and 14th day after medication.Results ①)Comparison on the incidence of DVT:The incidence of DVT in the treatment group was higher than the control group at 7th day after medication,this incidence turn to equal in the two groups at the 14th day after medication,while at the end of therapy,the incidence of DVT in the treatment group was lower than the control group with significant difference (P＜0.05).②Comparison on D-dimer changes:D-dimer at the 1st and 14th day were (0.782 ± 0.472) mg/1 and (0.320 ± 0.102) mg/1 in the treatment group and (0.720±0.421)mg/1 and (0.417 ± 0.217) mg/l in the control group.Comparing with the same group before treatment [the treatment group was(0.548±0.245)mg/1; the control group was (0.560±0.195) mg/l],D-dimer was increased at the 1 st day with obvious difference (P＜ 0.05),but reduced at the 14th day,without statistical difference (P＞0.05).Conclusion Buyang-huanwu decoction did not show good effects as low molecular heparin at the beginning of the treatment,but the its whole therapeutic effects and safety was better in treating lower limb deep vein thrombosis after major orthopedic surgery.
