CAJ | 학술논문

目的初步探讨低阻抗意念导入疗法(TIP)治疗抑郁症的电生理机制.方法将48例抑郁症患者采用随机信封法随机分为低阻抗状态下的意念导入疗法组(TIP组)24例,采用低阻抗状态下意念导入疗法治疗;氢溴酸西酞普兰片组24例,采用氢溴酸西酞普兰片治疗.两组疗程均为6个月,采用汉密尔顿抑郁量表(HAMD)评定疗效,多导睡眠图(PSG)探索电生理机制.结果 TIP组可以减少觉醒次数[疗前(3.92±3.24)次、疗后(2.38±1.21)次,P＜0.05]、缩短REM期睡眠时间[分别为疗前(86.75±28.29) min、疗后(63.19±28.11)min,P＜0.01]、降低REM睡眠百分比[疗前(23.89±6.84)％、疗后(16.16±6.36)％,P＜0.01]、降低NREM睡眠百分比[疗前(76.15±6.80)％、疗后(83.83±6.26)％,P＜0.05].氢溴酸西酞普兰片组可增加总睡眠时间[疗前(350.52±50.71)min、疗后(388.58±43.89) min,P＜0.01]、REM期次数[疗前(3.71±2.87)次、疗后(5.17±5.58)次,P＜0.05]、3+4期睡眠时间[疗前(35.79±32.76) min、疗后(56.77±34.21)min,P＜0.05]、3+4期睡眠百分比[疗前(10.13±9.20)％、疗后(14.53±8.66)％,P＜0.05]、REM期睡眠时间[(疗前(66.39±29.22) min、疗后(78.61±30.19) min,P＜0.05].TIP对觉醒次数、REM期时间的改善明显优于氢溴酸西酞普兰组.结论 TIP治疗抑郁症的电生理机制为减少觉醒次数、缩短REM期睡眠时间、降低REM睡眠百分比.
목적 초보탐토저조항의념도입요법(TIP)치료억욱증적전생리궤제.방법 장48례억욱증환자채용수궤신봉법수궤분위저조항상태하적의념도입요법조(TIP조)24례,채용저조항상태하의념도입요법치료;경추산서태보란편조24례,채용경추산서태보란편치료.량조료정균위6개월,채용한밀이돈억욱량표(HAMD)평정료효,다도수면도(PSG)탐색전생리궤제.결과 TIP조가이감소각성차수[료전(3.92±3.24)차、료후(2.38±1.21)차,P＜0.05]、축단REM기수면시간[분별위료전(86.75±28.29) min、료후(63.19±28.11)min,P＜0.01]、강저REM수면백분비[료전(23.89±6.84)％、료후(16.16±6.36)％,P＜0.01]、강저NREM수면백분비[료전(76.15±6.80)％、료후(83.83±6.26)％,P＜0.05].경추산서태보란편조가증가총수면시간[료전(350.52±50.71)min、료후(388.58±43.89) min,P＜0.01]、REM기차수[료전(3.71±2.87)차、료후(5.17±5.58)차,P＜0.05]、3+4기수면시간[료전(35.79±32.76) min、료후(56.77±34.21)min,P＜0.05]、3+4기수면백분비[료전(10.13±9.20)％、료후(14.53±8.66)％,P＜0.05]、REM기수면시간[(료전(66.39±29.22) min、료후(78.61±30.19) min,P＜0.05].TIP대각성차수、REM기시간적개선명현우우경추산서태보란조.결론 TIP치료억욱증적전생리궤제위감소각성차수、축단REM기수면시간、강저REM수면백분비.
Objective To observe the electronic physiological mechanism of Low Resistance Thought Induction Psychotherapy (TIP) on depression.Methods 48 patients with depression were randomly divided into TIP group and Citalopram group.The observation period was 6 months.The Hamilton Rating Scale for Depression(HAMD) was used to evaluate the efficacy,and Polysomnogram(PSG)was used to evaluate the electronic physiological mechanism.Results TIP had efficacy on reducing numbers of wake [before treatment (3.92±3.24),after treatment (2.38± 1.21),P＜0.05]、REM time [before treatment (86.75 ±28.29),after treatment (63.19±28.11),P＜0.01]、REM％ [before treatment (23.89±6.84),after treatment (16.16±6.36),P＜0.01].Citalopram had efficacy on increasing Sleep time [before treatment (350.52±50.71),after treatment (388.58±43.89),P＜0.01]、number of REM [before treatment (3.71±2.87),after treatment (5.17±5.58),P＜0.05]、S3+4 [before treatment (35.79±32.76),after treatment (56.77±34.21),P ＜0.05]、S3 +4％ [before treatment (10.13 ± 9.20),after treatment (14.53 ± 8.66),P＜0.05]、REM time [before treatment (66.39±29.22),after treatment(78.61 ±30.19),P＜0.05].TIP had superior to Citaloprarn on regulating numbers of wake and REM time.Conclusions Electronic physiological mechanism of TIP treating depression is to regulat numbers of wake,REM time,REM％.