国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2014年
2期
121-124
,共4页
红景天%最细粉%糖尿病肾病%保护作用
紅景天%最細粉%糖尿病腎病%保護作用
홍경천%최세분%당뇨병신병%보호작용
Rhodiola rosea%Superfine powder%Diabetic nephropathy%Protective effects
目的 研究红景天最细粉对糖尿病肾病(DN)大鼠的保护作用.方法 采用单侧肾脏切除并腹腔注射链脲佐菌素(STZ)的方法建立DN大鼠模型.将造模成功的大鼠按体质量排序编号,采用随机数字表法随机分为假手术组,DN模型组,红景天普通粉治疗组(3 g/kg·d-1),及红景天最细粉低剂量组(0.75 g/kg·d-1)、中剂量组(1.5 g/kg·d-1)、高剂量组(3 g/kg·d-1)各10只,均灌胃给药,1次/d.7周后,检测各组空腹血糖(FBG)、血清总胆固醇(STC)、尿素氮(BUN)、肌酐(Cr)、尿液尿蛋白(Upro);光镜观察各组肾组织的形态学改变.结果 DN模型组FBG、STC、BUN、Cr、Upro[分别为(24.78±3.66) mmol/L、(4.07±1.32) mmol/L、(22.36±2.54) mmol/L、(86.78±7.47) μmol/L、(50.23±6.82) mg],与红景天普通粉治疗组,红景天最细粉中、高剂量组的FBG[分别为(18.67±2.74) mmol/L、(17.21±3.17) mmol/L、(15.48±2.46) mmol/L]、STC[分别为(3.33±0.87) mmol/L、(3.42±0.74) mmol/L、(3.21±0.92) mmol/L],BUN[分别为(15.43±2.04) mmol/L、(16.56±1.85) mmol/L、(12.44±1.36) mmol/L]、Cr[分别为(66.17±4.43) μmol/L、(68.42±5.06) μmol/L、(61.33±4.21) μmol/L]、Upro[分别为(37.47±5.64) mg、(35.66±4.72) mg、(27.37±3.92) mg]比较均降低,差异有统计学意义(P＜0.05),且红景天最细粉高剂量组的疗效更佳.DN大鼠肾组织病理形态学观察表明,各红景天治疗组肾组织病理改变均减轻.结论 红景天对DN大鼠有保护作用,且相同剂量最细粉组的疗效优于普通粉组.
目的 研究紅景天最細粉對糖尿病腎病(DN)大鼠的保護作用.方法 採用單側腎髒切除併腹腔註射鏈脲佐菌素(STZ)的方法建立DN大鼠模型.將造模成功的大鼠按體質量排序編號,採用隨機數字錶法隨機分為假手術組,DN模型組,紅景天普通粉治療組(3 g/kg·d-1),及紅景天最細粉低劑量組(0.75 g/kg·d-1)、中劑量組(1.5 g/kg·d-1)、高劑量組(3 g/kg·d-1)各10隻,均灌胃給藥,1次/d.7週後,檢測各組空腹血糖(FBG)、血清總膽固醇(STC)、尿素氮(BUN)、肌酐(Cr)、尿液尿蛋白(Upro);光鏡觀察各組腎組織的形態學改變.結果 DN模型組FBG、STC、BUN、Cr、Upro[分彆為(24.78±3.66) mmol/L、(4.07±1.32) mmol/L、(22.36±2.54) mmol/L、(86.78±7.47) μmol/L、(50.23±6.82) mg],與紅景天普通粉治療組,紅景天最細粉中、高劑量組的FBG[分彆為(18.67±2.74) mmol/L、(17.21±3.17) mmol/L、(15.48±2.46) mmol/L]、STC[分彆為(3.33±0.87) mmol/L、(3.42±0.74) mmol/L、(3.21±0.92) mmol/L],BUN[分彆為(15.43±2.04) mmol/L、(16.56±1.85) mmol/L、(12.44±1.36) mmol/L]、Cr[分彆為(66.17±4.43) μmol/L、(68.42±5.06) μmol/L、(61.33±4.21) μmol/L]、Upro[分彆為(37.47±5.64) mg、(35.66±4.72) mg、(27.37±3.92) mg]比較均降低,差異有統計學意義(P＜0.05),且紅景天最細粉高劑量組的療效更佳.DN大鼠腎組織病理形態學觀察錶明,各紅景天治療組腎組織病理改變均減輕.結論 紅景天對DN大鼠有保護作用,且相同劑量最細粉組的療效優于普通粉組.
목적 연구홍경천최세분대당뇨병신병(DN)대서적보호작용.방법 채용단측신장절제병복강주사련뇨좌균소(STZ)적방법건립DN대서모형.장조모성공적대서안체질량배서편호,채용수궤수자표법수궤분위가수술조,DN모형조,홍경천보통분치료조(3 g/kg·d-1),급홍경천최세분저제량조(0.75 g/kg·d-1)、중제량조(1.5 g/kg·d-1)、고제량조(3 g/kg·d-1)각10지,균관위급약,1차/d.7주후,검측각조공복혈당(FBG)、혈청총담고순(STC)、뇨소담(BUN)、기항(Cr)、뇨액뇨단백(Upro);광경관찰각조신조직적형태학개변.결과 DN모형조FBG、STC、BUN、Cr、Upro[분별위(24.78±3.66) mmol/L、(4.07±1.32) mmol/L、(22.36±2.54) mmol/L、(86.78±7.47) μmol/L、(50.23±6.82) mg],여홍경천보통분치료조,홍경천최세분중、고제량조적FBG[분별위(18.67±2.74) mmol/L、(17.21±3.17) mmol/L、(15.48±2.46) mmol/L]、STC[분별위(3.33±0.87) mmol/L、(3.42±0.74) mmol/L、(3.21±0.92) mmol/L],BUN[분별위(15.43±2.04) mmol/L、(16.56±1.85) mmol/L、(12.44±1.36) mmol/L]、Cr[분별위(66.17±4.43) μmol/L、(68.42±5.06) μmol/L、(61.33±4.21) μmol/L]、Upro[분별위(37.47±5.64) mg、(35.66±4.72) mg、(27.37±3.92) mg]비교균강저,차이유통계학의의(P＜0.05),차홍경천최세분고제량조적료효경가.DN대서신조직병리형태학관찰표명,각홍경천치료조신조직병리개변균감경.결론 홍경천대DN대서유보호작용,차상동제량최세분조적료효우우보통분조.
Objective To study the renal protective effects of superfine powder of Rhodiola rosea in diabetic nephropathy (DN)rats.Methods The DN rats model was established by one side nephrectomy and intraperitoneal injection of streptozotocin(STZ).Then rats were randomly divided into 6 groups:sham-operation group,model group,Rhodiola rosea common powder groups(3 g/kg·d-1),and superfine powder of low,medium and high dose groups (0.75、1.5、3.0 g/kg·d 1),10 rats in each group.Rats were given the relevant drugs respectively for 7 weeks.Finally the levels of fasting blood glucose (FBG),serum total cholesterol (STC),blood urea nitrogen (BUN),creatinine (Cr) and urinary protein (Upro) were detected.The kidney tissue was taken for histopathological observation.Results Compared with DN modelgroup [FBG,STC,BUN,Cr and Upro was (24.78±3.66)mmol/L,(4.07±1.32)mmol/L,(22.36±2.54)mmol/L,(86.78±7.47) μmol/L,(50.23±6.82)mg respectively],the rats in DN model group after treatment with common and superfine powder (medium and high dose groups) of Rhodiola rosea appeared different levels of improvement ofFBG [(18.67±2.74) mmol/L,(17.21 ±3.17)mmol/L,(15.48±2.46) mmol/L],STC [(3.33±0.87) mmol/L,(3.42 ± 0.74) mmol/L,(3.21 ±0.92)mmol/L],BUN [(15.43±2.04)mmol/L,(16.56±1.85)mmol/L,(12.44±1.36)mmol/L],Cr [(66.17 ± 4.43) μmol/L,(68.42 ± 5.06) μmol/L,(61.33±4.21)μmol/L] and Upro [(37.47±5.64) mg、(35.66 ± 4.72) mg,(27.37± 3.92) mg],P＜ 0.05.The pathologic changes of kidney tissue were improved,too.Conclusion Rhodiola rosea has a good renal protective effect in rats with DN.Furthermore,the superfine powder is more effective than the common powder in renal protective effects.
