国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2014年
2期
128-130
,共3页
王嵩%李荣%龚兆会%刘煜德%郑雪洁%吴伟
王嵩%李榮%龔兆會%劉煜德%鄭雪潔%吳偉
왕숭%리영%공조회%류욱덕%정설길%오위
补肾益心片%缬沙坦%高血压%血管紧张素1-7
補腎益心片%纈沙坦%高血壓%血管緊張素1-7
보신익심편%힐사탄%고혈압%혈관긴장소1-7
Bushenyixin tablet%Valsartan%Essential hypertension%Ang1-7
目的 观察补肾益心片对高血压大鼠(SHR)一氧化氮合酶(NOS)、一氧化氮(NO)及血管紧张素1-7 (Ang 1-7)的调节作用.方法 将原发高血压雄性大鼠按随机数字表法随机分为补肾益心片组(8只)、缬沙坦组(8只)、高血压模型组(7只),分别予以补肾益心片、缬沙坦、生理盐水灌胃.治疗4周后,检测大鼠血浆、腹主动脉组织内NOS、NO浓度以及血浆Ang1-7浓度.结果 补肾益心片组可降低血浆NO(15.500±4.375)μmol/L、提高腹主动脉NO (35.604±7.505) μmol/L及血浆Ang1-7(45.542±12.726) ng/L,与高血压模型组[分别为(26.000±2.828)μmol/L、(17.437±11.649) μmol/L、(25.521±2.727) ng/L].比较,差异有统计学意义(P＜0.05).其中,补肾益心片组大鼠腹主动脉NO水平较缬沙坦组[(21.537±13.484) μmol/L]显著升高,差异有统计学意义(P＜0.05).结论 补肾益心片可增加高血压大鼠腹主动脉NO、血浆Ang1-7含量.
目的 觀察補腎益心片對高血壓大鼠(SHR)一氧化氮閤酶(NOS)、一氧化氮(NO)及血管緊張素1-7 (Ang 1-7)的調節作用.方法 將原髮高血壓雄性大鼠按隨機數字錶法隨機分為補腎益心片組(8隻)、纈沙坦組(8隻)、高血壓模型組(7隻),分彆予以補腎益心片、纈沙坦、生理鹽水灌胃.治療4週後,檢測大鼠血漿、腹主動脈組織內NOS、NO濃度以及血漿Ang1-7濃度.結果 補腎益心片組可降低血漿NO(15.500±4.375)μmol/L、提高腹主動脈NO (35.604±7.505) μmol/L及血漿Ang1-7(45.542±12.726) ng/L,與高血壓模型組[分彆為(26.000±2.828)μmol/L、(17.437±11.649) μmol/L、(25.521±2.727) ng/L].比較,差異有統計學意義(P＜0.05).其中,補腎益心片組大鼠腹主動脈NO水平較纈沙坦組[(21.537±13.484) μmol/L]顯著升高,差異有統計學意義(P＜0.05).結論 補腎益心片可增加高血壓大鼠腹主動脈NO、血漿Ang1-7含量.
목적 관찰보신익심편대고혈압대서(SHR)일양화담합매(NOS)、일양화담(NO)급혈관긴장소1-7 (Ang 1-7)적조절작용.방법 장원발고혈압웅성대서안수궤수자표법수궤분위보신익심편조(8지)、힐사탄조(8지)、고혈압모형조(7지),분별여이보신익심편、힐사탄、생리염수관위.치료4주후,검측대서혈장、복주동맥조직내NOS、NO농도이급혈장Ang1-7농도.결과 보신익심편조가강저혈장NO(15.500±4.375)μmol/L、제고복주동맥NO (35.604±7.505) μmol/L급혈장Ang1-7(45.542±12.726) ng/L,여고혈압모형조[분별위(26.000±2.828)μmol/L、(17.437±11.649) μmol/L、(25.521±2.727) ng/L].비교,차이유통계학의의(P＜0.05).기중,보신익심편조대서복주동맥NO수평교힐사탄조[(21.537±13.484) μmol/L]현저승고,차이유통계학의의(P＜0.05).결론 보신익심편가증가고혈압대서복주동맥NO、혈장Ang1-7함량.
Objective To study the variation of the level of NOS,NO and Ang (1-7) in spontaneously hypertensive rat(SHR).Methods SHR were divided randomly into 3 groups:Bushenyixin group(n=8),valsartan group (n=8),and model group (n=7).Each group was given Bushenyixin tablet,valsartan,and saline by gavage respectively.After 4 weeks,the concentration of NOS,NO,Ang (1-7) in plasma and the concentration of NOS,NO in aorta were be observed.Results The concentration of NO in plasma was significantly lower in the Bushen-Yxin group than for model group(15.500±4.375)μmol/L vs.(26.000±2.828)gmol/L,P＜0.05.The concentration of NO in aorta and Ang1-7 in plasma were significantly higher in the Bushen-Yixin group than in the model group [(35.604±7.505)μmol/L vs.(17.437± 11.649) μ mol/L,(45.542 ± 12.726)ng/L vs.(25.521 ± 2.727) ng/L,P＜0.05].The concentration of NO in aorta was significantly higher in Bushen-Yixin group than in the valsartan group [(21.537± 13.484) μmol/L,P＜0.05].Conclusion Bushen-Yixin tablet had effects of increasing of NO level in aorta and Ang (1-7) level in plasma in spontaneously hypertensive rat.
