国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2014年
3期
213-216
,共4页
唐瑭%陈德森%李莉%朱克刚
唐瑭%陳德森%李莉%硃剋剛
당당%진덕삼%리리%주극강
通痹外敷膏%膝关节骨性关节炎%关节腔冲洗%细胞介素-1β%透明质酸
通痺外敷膏%膝關節骨性關節炎%關節腔遲洗%細胞介素-1β%透明質痠
통비외부고%슬관절골성관절염%관절강충세%세포개소-1β%투명질산
Tongbi topical ointment%Knee osteoarthritis%Joint cavity flushing%Interleukin-1 beta%Hyaluronic acid
目的 观察中药通痹外敷膏联合关节腔冲洗术治疗膝骨性关节炎合并关节积液的疗效.方法 收集2009年5月至2013年3月湖北医药学院附属太和医院针灸科膝关节骨性关节炎伴关节积液患者366例,采用随机数字表法将患者分为两组各183例,对照组采用口服盐酸氨基葡萄糖胶囊及关节腔冲洗术治疗,治疗组在对照组治疗基础上外敷通痹外敷膏治疗.分别于治疗前后测定关节炎积液中白细胞介素-1β(IL-1β)、透明质酸(HA)含量;采用视觉模拟评分量表(VAS)及加拿大西安大略和麦克玛斯特大学膝关节骨关节炎指数(WOMAC)评价临床疗效.结果 治疗前及治疗后4周,治疗组IL-1β[分别为(39.29±7.52) pg/ml、(28.33±5.42) pg/ml]明显降低;HA含量[分别为(1.41±0.23) μg/L、(3.34±0.48) μg/L]明显升高;VAS评分[治疗前及后第1～4周分别为(7.21±0.35)分、(5.47±0.34)分、(5.04±0.32)分、(4.03±0.24)分、(2.23±0.15)分]逐步降低;WOMAC指数[治疗前及后第1～4周分别为(56.17±7.31)分、(46.32±6.34)分、(37.17±5.31)分、(29.04±3.58)分、(15.21±2.37)分]明显好转,与对照组治疗后第3、4周比较差异均有统计学意义(P＜0.05).治疗组总有效率为98.9％(181/183)、对照组为87.4％ (160/183),两组比较,差异有统计学意义(x2=5.671,P＜0.01).结论 通痹外敷膏联合关节腔冲洗可有效治疗膝骨性关节炎合并积液.
目的 觀察中藥通痺外敷膏聯閤關節腔遲洗術治療膝骨性關節炎閤併關節積液的療效.方法 收集2009年5月至2013年3月湖北醫藥學院附屬太和醫院針灸科膝關節骨性關節炎伴關節積液患者366例,採用隨機數字錶法將患者分為兩組各183例,對照組採用口服鹽痠氨基葡萄糖膠囊及關節腔遲洗術治療,治療組在對照組治療基礎上外敷通痺外敷膏治療.分彆于治療前後測定關節炎積液中白細胞介素-1β(IL-1β)、透明質痠(HA)含量;採用視覺模擬評分量錶(VAS)及加拿大西安大略和麥剋瑪斯特大學膝關節骨關節炎指數(WOMAC)評價臨床療效.結果 治療前及治療後4週,治療組IL-1β[分彆為(39.29±7.52) pg/ml、(28.33±5.42) pg/ml]明顯降低;HA含量[分彆為(1.41±0.23) μg/L、(3.34±0.48) μg/L]明顯升高;VAS評分[治療前及後第1～4週分彆為(7.21±0.35)分、(5.47±0.34)分、(5.04±0.32)分、(4.03±0.24)分、(2.23±0.15)分]逐步降低;WOMAC指數[治療前及後第1～4週分彆為(56.17±7.31)分、(46.32±6.34)分、(37.17±5.31)分、(29.04±3.58)分、(15.21±2.37)分]明顯好轉,與對照組治療後第3、4週比較差異均有統計學意義(P＜0.05).治療組總有效率為98.9％(181/183)、對照組為87.4％ (160/183),兩組比較,差異有統計學意義(x2=5.671,P＜0.01).結論 通痺外敷膏聯閤關節腔遲洗可有效治療膝骨性關節炎閤併積液.
목적 관찰중약통비외부고연합관절강충세술치료슬골성관절염합병관절적액적료효.방법 수집2009년5월지2013년3월호북의약학원부속태화의원침구과슬관절골성관절염반관절적액환자366례,채용수궤수자표법장환자분위량조각183례,대조조채용구복염산안기포도당효낭급관절강충세술치료,치료조재대조조치료기출상외부통비외부고치료.분별우치료전후측정관절염적액중백세포개소-1β(IL-1β)、투명질산(HA)함량;채용시각모의평분량표(VAS)급가나대서안대략화맥극마사특대학슬관절골관절염지수(WOMAC)평개림상료효.결과 치료전급치료후4주,치료조IL-1β[분별위(39.29±7.52) pg/ml、(28.33±5.42) pg/ml]명현강저;HA함량[분별위(1.41±0.23) μg/L、(3.34±0.48) μg/L]명현승고;VAS평분[치료전급후제1～4주분별위(7.21±0.35)분、(5.47±0.34)분、(5.04±0.32)분、(4.03±0.24)분、(2.23±0.15)분]축보강저;WOMAC지수[치료전급후제1～4주분별위(56.17±7.31)분、(46.32±6.34)분、(37.17±5.31)분、(29.04±3.58)분、(15.21±2.37)분]명현호전,여대조조치료후제3、4주비교차이균유통계학의의(P＜0.05).치료조총유효솔위98.9％(181/183)、대조조위87.4％ (160/183),량조비교,차이유통계학의의(x2=5.671,P＜0.01).결론 통비외부고연합관절강충세가유효치료슬골성관절염합병적액.
Objective To observe the curative effect of traditional Chinese medicine on the treatment of osteoarthritis of the knee with Tongbi topical ointment combined with joint cavity effusion flushing.Methods 366 patients of osteoarthritis of knee joint with effusion were collected from May 2009 to March 2013 in Hubei University of Medicine Affiliated Taihe Hospital,and randomly recruited into a control group and a treatment group by random number table method,with 188 patients in each group.The control group was treated with the joint cavity drainage and oral taking glucosamine hydrochloride capsules,the treatment group was treated with external application of Tongbi ointment based on the control group.Leukocyte osteoarthritis-1 beta (IL-1β) and hyaluronic acid (HA) were measured before and after the treatment.VAS and WOMAC osteoarthritis index were used to evaluate the effect.Results Compared with indexes before the treatment,IL-1β[(39.29±7.52) pg/ml,(28.33 ± 5.42) pg/ml] decreased significantly,HA content [(1.41 ± 0.23) μg/L,(3.34± 0.48) μg/L] increased significantly,VAS score [before treatment and 1-4weeks were (7.21±0.35),(5.47±0.34),(5.04±0.32),(4.03±0.24),(2.23±0.15)] decreased and the WOMAC index[(56.17±7.31),(46.32±6.34),(37.17± 5.31),(29.04±3.58),(15.21 ±2.37)] improved significantly in the treatment group after 4 weeks of treatment.There was a significant difference between the treatment and the control group showed (P＜0.05).Combined with the total effective rate of 98.9％ (181/183) in treatment group,the control group of 87.4％ (160/183) showed a significant difference (P＜0.01).Conclusion External application of Tongbi ointment combined with joint cavity flushing was effective in the treatment of osteoarthritis of the knee with effusion.
