CAJ | 학술논문

目的通过Meta分析对超声和增强CT(CECT)诊断甲状腺癌颈部淋巴结转移的临床价值进行评价.方法在美国生物医学数据库、荷兰医学文摘、Cochrance协作网和中国生物医学文献数据库中检索1995年1月-2012年12月以病理结果为金标准的关于超声、CECT诊断甲状腺癌颈部淋巴结转移的中英文文献,对纳入文献进行质量评价.采用Meta-Disc 1.4软件计算出汇总敏感度和特异度及95％可信区间,并绘制ROC曲线,得出Q*值,进行Z检验.结果共17篇(1 682例)文献被纳入.超声、CECT的合并敏感度和合并特异度分别为0.62、0.61和0.92、0.86.二者的ROC曲线下面积分别为0.84、0.82,二者Q*值(0.7718和0.7561)差异无统计学意义(P=0.78).结论诊断甲状腺癌颈部淋巴结转移,超声与CECT诊断价值相当,但超声的特异度高于CECT.
목적 통과Meta분석대초성화증강CT(CECT)진단갑상선암경부림파결전이적림상개치진행평개.방법 재미국생물의학수거고、하란의학문적、Cochrance협작망화중국생물의학문헌수거고중검색1995년1월-2012년12월이병리결과위금표준적관우초성、CECT진단갑상선암경부림파결전이적중영문문헌,대납입문헌진행질량평개.채용Meta-Disc 1.4연건계산출회총민감도화특이도급95％가신구간,병회제ROC곡선,득출Q*치,진행Z검험.결과 공17편(1 682례)문헌피납입.초성、CECT적합병민감도화합병특이도분별위0.62、0.61화0.92、0.86.이자적ROC곡선하면적분별위0.84、0.82,이자Q*치(0.7718화0.7561)차이무통계학의의(P=0.78).결론 진단갑상선암경부림파결전이,초성여CECT진단개치상당,단초성적특이도고우CECT.
Objective To evaluate the clinical value of ultrasound (US) and contrast-enhanced CT (CECT) in the diagnosis of cervical lymph nodes metastasis in patients with thyroid carcinoma by a meta-analysis.Methods Literature search was performed in Medline,Embase,Cochrane,CBM datebases to identify relevant English and Chinese literatures with pathological result as the gold standard from January 1995 to December 2012.The quality of each selected study was evaluated by QUADAS.The Meta-disc 1.4 software was used to calculate the pooled sensitivity,specificity and the corresponding 95％ CI.Summary receiver operating characteristic curves (ROC),area under curve (AUC) and the Q * index were calculated and used to evaluate the diagnostic efficiency of the two methods by Z test.Results Totally seventeen literatures (1 682 patients) were included,the pooled sensitivity and specificity for and CECT scanning were 0.62,0.61 and 0.92,0.86.The AUC of the two were 0.84,0.82 respectively.There was no statistically significant difference between US and CT (P =0.78) in the Q* index(0.7718,0.7561).Conclusions US and CECT have similar value in the diagnosis of cervical lymph nodes metastasis in patients with thyroid carcinoma,but there is higher specificity in US than that in CECT.