中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2013年
2期
180-184
,共5页
催乳素%细胞免疫%体液免疫%危重症%预后%内分泌系统%免疫调节%急性生理学与慢性健康状况评分系统
催乳素%細胞免疫%體液免疫%危重癥%預後%內分泌繫統%免疫調節%急性生理學與慢性健康狀況評分繫統
최유소%세포면역%체액면역%위중증%예후%내분비계통%면역조절%급성생이학여만성건강상황평분계통
Prolactin%Cell immunity%Humoral immunity%Critically ill%Prognosis%Endocrine system%Immunoregulation%Acute physiology and chronic health evaluation Ⅱ
目的 本研究探讨危重症患者血清催乳素(prolactin,PRL)水平、免疫功能改变及预后的关系.方法 选择福建省立医院内科重症监护室2010年10月1日至2011年10月1日收治的符合标准资料完整的80例危重症患者,根据预后分为死亡组与存活组.分别于入院第2天、第4天、第8天早晨抽取空腹血,用化学发光免疫分析系统检测其外周血血清PRL,流式细胞仪检测其外周血中T淋巴细胞亚群,免疫速率散射比浊法检测其外周血中体液免疫五项,并用多因素重复测量方差分析对两组进行比较分析.结果 和存活组比较,死亡组危重症患者血清PRL值(P为0.037,0.036,0.030)和外周血CD3+(P为0.034,0.023,0.023)、CD4+(P为0.046,0.003,0.046)、CD8+(P为0.040 1,0.039,0.045)细胞百分数明显低于存活组.血清PRL值和CD3+、CD4+、CD8+正相关(P为0.004,0.043,0.003),血清PRL值越高,CD3+、CD4+、CD8+细胞百分数越高.结论 细胞免疫的改变,对患者的预后有重要影响,细胞免疫下降,提示预后不良.血清PRL对细胞免疫功能可能有着正调节作用.
目的 本研究探討危重癥患者血清催乳素(prolactin,PRL)水平、免疫功能改變及預後的關繫.方法 選擇福建省立醫院內科重癥鑑護室2010年10月1日至2011年10月1日收治的符閤標準資料完整的80例危重癥患者,根據預後分為死亡組與存活組.分彆于入院第2天、第4天、第8天早晨抽取空腹血,用化學髮光免疫分析繫統檢測其外週血血清PRL,流式細胞儀檢測其外週血中T淋巴細胞亞群,免疫速率散射比濁法檢測其外週血中體液免疫五項,併用多因素重複測量方差分析對兩組進行比較分析.結果 和存活組比較,死亡組危重癥患者血清PRL值(P為0.037,0.036,0.030)和外週血CD3+(P為0.034,0.023,0.023)、CD4+(P為0.046,0.003,0.046)、CD8+(P為0.040 1,0.039,0.045)細胞百分數明顯低于存活組.血清PRL值和CD3+、CD4+、CD8+正相關(P為0.004,0.043,0.003),血清PRL值越高,CD3+、CD4+、CD8+細胞百分數越高.結論 細胞免疫的改變,對患者的預後有重要影響,細胞免疫下降,提示預後不良.血清PRL對細胞免疫功能可能有著正調節作用.
목적 본연구탐토위중증환자혈청최유소(prolactin,PRL)수평、면역공능개변급예후적관계.방법 선택복건성립의원내과중증감호실2010년10월1일지2011년10월1일수치적부합표준자료완정적80례위중증환자,근거예후분위사망조여존활조.분별우입원제2천、제4천、제8천조신추취공복혈,용화학발광면역분석계통검측기외주혈혈청PRL,류식세포의검측기외주혈중T림파세포아군,면역속솔산사비탁법검측기외주혈중체액면역오항,병용다인소중복측량방차분석대량조진행비교분석.결과 화존활조비교,사망조위중증환자혈청PRL치(P위0.037,0.036,0.030)화외주혈CD3+(P위0.034,0.023,0.023)、CD4+(P위0.046,0.003,0.046)、CD8+(P위0.040 1,0.039,0.045)세포백분수명현저우존활조.혈청PRL치화CD3+、CD4+、CD8+정상관(P위0.004,0.043,0.003),혈청PRL치월고,CD3+、CD4+、CD8+세포백분수월고.결론 세포면역적개변,대환자적예후유중요영향,세포면역하강,제시예후불량.혈청PRL대세포면역공능가능유착정조절작용.
Objective To clarify the relationship between the serum prolactin (PRL),immunity and prognosis of the critical patients.Methods The data of 80 patients with complete clinical data in the Intensive Care Unit of the Fujian Provincial Hospital during October 1,2010 to October 1,2011 were collected.The patients were divided into 2 groups according to the prognosis:death group and survival group.Fasting blood is extracted respectively on the morning of the 2nd day after they were admitted,the 4th day and the 8th day.Chemiluminescence immunoassay system was used to detect the serum PRL,flow cytometers to test peripheral blood T-lymphocyte subsets,and immunization rate nephelometry to check the 5 items for bumoral immunity in peripheral blood.The multi-factor repeated measure analysis of variance was used in the comparison of the two groups.Results Compared with those of the survival group,the serum PRL (P=0.037,0.036,0.030),the percentages of CD3+ (P=0.034,0.023,0.023),CD4+ (P =0.046,0.003,0.046) and CD8+ (P =0.040,0.039,0.045) cells of the death group were significantly lower.However,positive correlation exists between the value of serum PRL and the percentages ofCD3+,CD4+ and CD8+ cells (P=0.004,0.043,0.003):the higher the former,the higher the latter.Conclusions The change of cellular immunity is important for the prognosis of the patients.Downgradationof the cellular innunity indicates an undesirable prognosis.The serum PRL may work positively on cellular immunity.
