CAJ | 학술논문

目的分析和观察肾动脉支架置入术治疗肾动脉狭窄的疗效性和安全性.方法 2003年1月至2012年6月,江西省人民医院50例单侧或双侧肾动脉狭窄≥70％的高血压患者,其中男性32例,女性18例,年龄21～78岁,(51.2±12.3)岁,均经股动脉或桡动脉途径行肾动脉支架置入术,并定期随访6个月,观察血压、降压药物和肾功能的动态变化.计量资料采用t检验.结果肾动脉支架技术成功率为100％.50例患者中高血压治愈16例(32％)、改善30例(60％)、无效4例(8％).与术前相比较,6月术后患者血压明显下降[收缩压(145.7 ±11.3) mmHg vs.(179.1±22.3)mmHg(1mmHg =0.133 kPa),舒张压[(75.1±9.2) mmHg vs.(112.5±19.2) mmHg],降压药物种类减少,血肌酐(sCr)下降[(138.2±20.3) μmol/L vs.(191.1±36.5) μmol/L],差异具有统计学意义(均P＜0.05).围手术期和随访期间,无严重并发症和死亡发生.结论肾动脉支架置入术临床疗效肯定,手术成功率高,并具有一定的肾功能保护作用.
목적 분석화관찰신동맥지가치입술치료신동맥협착적료효성화안전성.방법 2003년1월지2012년6월,강서성인민의원50례단측혹쌍측신동맥협착≥70％적고혈압환자,기중남성32례,녀성18례,년령21～78세,(51.2±12.3)세,균경고동맥혹뇨동맥도경행신동맥지가치입술,병정기수방6개월,관찰혈압、강압약물화신공능적동태변화.계량자료채용t검험.결과 신동맥지가기술성공솔위100％.50례환자중고혈압치유16례(32％)、개선30례(60％)、무효4례(8％).여술전상비교,6월술후환자혈압명현하강[수축압(145.7 ±11.3) mmHg vs.(179.1±22.3)mmHg(1mmHg =0.133 kPa),서장압[(75.1±9.2) mmHg vs.(112.5±19.2) mmHg],강압약물충류감소,혈기항(sCr)하강[(138.2±20.3) μmol/L vs.(191.1±36.5) μmol/L],차이구유통계학의의(균P＜0.05).위수술기화수방기간,무엄중병발증화사망발생.결론 신동맥지가치입술림상료효긍정,수술성공솔고,병구유일정적신공능보호작용.
Objective To explore the short term efficacy and safety of percutaneous transluminal renal artery stenting in patient with renal artery stenosis.Methods From January 2003 through June 2012,fifty hypertension patients with unilateral or bilateral renal artery stenosis ≥70％ were successfully treated by percutaneous translumminal renal angioplasty with stent (PTRAS).There were 32 males and 18 females with an average age of (51.2 ± 12.3) years ranged from 21 ～78 years.The blood pressure level,dosage of anti-hypertension drugs and serum creatinine (Scr) of patients were documented and analyzed before and after stenting.All patients were clinically followed up for 6 months after stenting.Continuous variables were analyzed by using t-test for comparison among patients.Results The technical success rate was 100％.Of them,16 patients were cured,30 patients improved and 4 patients ineffective.There were significant differences in blood pressure,sCr and dosage of anti-hypertension drugs between post-stenting and prestenting [SBP (145.7 ±11.3) vs.(179.1 ±22.3) mmHg; DBP [(75.1±9.2) vs.(112.5 ±19.2)mmHg],sCr [(138.2 ±20.3) vs.(191.1 ±36.5) μmol/L] (P＜0.01) and the dosage of antihypertension drug was dramatically decreased.And there were no adverse events found during follow-up period.Conclusions The success rate of PTRAS technique was high,and the blood pressure of patients could be effectively controlled by it,being beneficial to renal function.