CAJ | 학술논문

目的探讨细胞DNA定量学分析在诊断乳腺疾病中的意义.方法收集2005年2月至2006年1月武汉中心医院病理科确诊的乳腺疾病128例,其中良性病变72例,交界性病变10例,恶性病变46例,应用全自动细胞图像分析仪测定128例乳腺疾病的DNA指数,并比较各组DNA倍体的阳性率.结果乳腺良性病变DNA倍体的阳性率为1.39％ (1/72),交界性病变的阳性率为30.00％ (3/10),恶性疾病的阳性率为78.26％(36/46),各组间差异有统计学意义(P＜0.05)；在乳腺浸润性导管癌中,组织学分级Ⅰ、Ⅱ、Ⅲ级的阳性率分别为57.14％(4/7),76.47％(13/17),100％(18/18).结论全自动细胞图像分析仪的细胞定量诊断DNA倍体分析对乳腺癌恶性程度及预后的评估有一定参考价值.
목적 탐토세포DNA정량학분석재진단유선질병중적의의.방법 수집2005년2월지2006년1월무한중심의원병이과학진적유선질병128례,기중량성병변72례,교계성병변10례,악성병변46례,응용전자동세포도상분석의측정128례유선질병적DNA지수,병비교각조DNA배체적양성솔.결과 유선량성병변DNA배체적양성솔위1.39％ (1/72),교계성병변적양성솔위30.00％ (3/10),악성질병적양성솔위78.26％(36/46),각조간차이유통계학의의(P＜0.05)；재유선침윤성도관암중,조직학분급Ⅰ、Ⅱ、Ⅲ급적양성솔분별위57.14％(4/7),76.47％(13/17),100％(18/18).결론 전자동세포도상분석의적세포정량진단DNA배체분석대유선암악성정도급예후적평고유일정삼고개치.
Objective To evaluate the value of DNA quantitative analysis in diagnosis of breast tumor.Methods The data of 128 cases diagnosed with breast disease from Feb.2005 to Jan.2006 in Department of Pathology in Wuhan Center Hospital were collected,among whom 72 cases had benign breast lesion,10 cases had boundary breast lesion and 46 cases had malignant breast disease.Automated DNA imaging cytometry was used to identify DNA indexes of the 128 cases.Results The positive rate was 1.39％ (1/72),30.00％ (3/10) and 78.26％ (36/46) respectively in benign breast lesion,boundary breast lesion and malignant breast disease.The difference had statistical significance (P ＜ 0.05).In invasive ductal breast cancer,the positive rate was 57.14％ (4/7),76.47％ (13/17) and 100％ (18/18) respectively for breast cancer of grade Ⅰ,Ⅱ and Ⅲ.Conclusion Automated DNA imaging cytometry is of some value in analyzing the malignant grade of breast cancer and predicting the prognosis of breast diseases.