中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2013年
2期
157-159
,共3页
2型糖尿病%动脉粥样硬化%黄嘌呤氧化酶
2型糖尿病%動脈粥樣硬化%黃嘌呤氧化酶
2형당뇨병%동맥죽양경화%황표령양화매
Type 2 diabetes%Atherosclerosis%Xanthine oxidoreductase
目的 观察2型糖尿病患者血清黄嘌呤氧化酶活性,探讨黄嘌呤氧化酶在疾病发病中的意义.方法 以270例2型糖尿病患者和140例健康对照者为研究对象,测量其身高、体重,空腹取血检测黄嘌呤氧化酶活性、血脂、血糖及尿酸水平等临床生化指标.结果 2型糖尿病患者黄嘌呤氧化酶活性显著高于健康对照组,差异有统计学意义(31.2±8.91vs4.6±0.91 U/L,P＜0.01)；有下肢血管并发症的2型糖尿病组血清黄嘌呤氧化酶活性显著高于无下肢血管并发症组,差异有统计学意义(42.1 ±8.43 vs23.7 ±5.31 U/L,P＜0.01).结论 黄嘌呤氧化酶通过多种分子机制密切介入2型糖尿病的发生发展过程.
目的 觀察2型糖尿病患者血清黃嘌呤氧化酶活性,探討黃嘌呤氧化酶在疾病髮病中的意義.方法 以270例2型糖尿病患者和140例健康對照者為研究對象,測量其身高、體重,空腹取血檢測黃嘌呤氧化酶活性、血脂、血糖及尿痠水平等臨床生化指標.結果 2型糖尿病患者黃嘌呤氧化酶活性顯著高于健康對照組,差異有統計學意義(31.2±8.91vs4.6±0.91 U/L,P＜0.01)；有下肢血管併髮癥的2型糖尿病組血清黃嘌呤氧化酶活性顯著高于無下肢血管併髮癥組,差異有統計學意義(42.1 ±8.43 vs23.7 ±5.31 U/L,P＜0.01).結論 黃嘌呤氧化酶通過多種分子機製密切介入2型糖尿病的髮生髮展過程.
목적 관찰2형당뇨병환자혈청황표령양화매활성,탐토황표령양화매재질병발병중적의의.방법 이270례2형당뇨병환자화140례건강대조자위연구대상,측량기신고、체중,공복취혈검측황표령양화매활성、혈지、혈당급뇨산수평등림상생화지표.결과 2형당뇨병환자황표령양화매활성현저고우건강대조조,차이유통계학의의(31.2±8.91vs4.6±0.91 U/L,P＜0.01)；유하지혈관병발증적2형당뇨병조혈청황표령양화매활성현저고우무하지혈관병발증조,차이유통계학의의(42.1 ±8.43 vs23.7 ±5.31 U/L,P＜0.01).결론 황표령양화매통과다충분자궤제밀절개입2형당뇨병적발생발전과정.
Objective Increased serum uric acid level is associated with type 2 diabetes (T2DM) through the mechanism of oxidative stress.As the rate-limiting enzyme in the degradation of purines in humans,xanthine oxidoreductase (XOR)catalyzes the final two reactions of purine catabolism,oxidizing hypoxanthine to xanthine,and xanthine to uric acid.The aim of this study is to investigate the association between serum XOR activity and T2DM.Methods A total of 270 patients with T2DM and 140 age-and-gender-matched health controls were enrolled in the study.The clinical examinations such as weight and height were conducted in the morning after an overnight fast.Serum XOR activity and other biochemical parameters like triglyceride,total cholesterol,high density lipoprotein cholesterol,fasting plasma glucose and uric acid levels were measured.Results Serum XOR activity was significantly elevated in T2DM patients compared with that in the controls (31.2 ± 8.91 vs 4.6 ± 0.91 U/L,P ＜0.01).Serum XOR activity was significantly elevated in T2DM patients complicated with lower extremity arterial disease compared to that in patients without lower extremity arterial disease (42.1 ± 8.43 vs 23.7 ± 5.31 U/L,P ＜ 0.01).Conclusion High XOR activity plays an important role in onset and development of T2DM.
