CAJ | 학술논문

目的探讨血浆瘦素(leptin)与5羟色胺(5-HT)之间的关系及2者在早泄诊断中的意义.方法招募71例终身性早泄患者为试验组及64例正常男性为对照组.予试验组为期8周盐酸舍曲林治疗,对照组不予治疗.测定受试者治疗前后血浆leptin及5-HT水平,并通过射精潜伏期、中国早泄患者性功能评分表对射精功能进行评估.结果治疗前试验组血浆leptin水平明显高于对照组,而5-HT水平低于对照组.8周后试验组血浆leptin水平下降,与正常对照组比较,差异无统计学意义(P＞0.05),而血浆5-HT水平大幅上升并趋于对照组水平.对于早泄,瘦素的敏感性和特异性分别为87.5％和96.3％,5-羟色胺的敏感性和特异性为92.2％和93.0％.结论血浆高水平leptin与低水平5-HT是早泄患者的生物学指标,这2者的测定对诊断早泄具有重要指导意义.
목적 탐토혈장수소(leptin)여5간색알(5-HT)지간적관계급2자재조설진단중적의의.방법 초모71례종신성조설환자위시험조급64례정상남성위대조조.여시험조위기8주염산사곡림치료,대조조불여치료.측정수시자치료전후혈장leptin급5-HT수평,병통과사정잠복기、중국조설환자성공능평분표대사정공능진행평고.결과 치료전시험조혈장leptin수평명현고우대조조,이5-HT수평저우대조조.8주후시험조혈장leptin수평하강,여정상대조조비교,차이무통계학의의(P＞0.05),이혈장5-HT수평대폭상승병추우대조조수평.대우조설,수소적민감성화특이성분별위87.5％화96.3％,5-간색알적민감성화특이성위92.2％화93.0％.결론 혈장고수평leptin여저수평5-HT시조설환자적생물학지표,저2자적측정대진단조설구유중요지도의의.
Objective To investigate the interrelationship between leptin and 5-hydroxy tryptamine (5-HT)and their significance in diagnosis of premature ejaculation(PE).Methods 71 cases with lifelong PE(the trial group)and 64 healthy males(the control group)were enrolled in this case-control study.Baseline recording of intravaginal ejaculation latency time(IELT) using a stop watch and Chinese Index of Premature Ejaculation-5 (CIPE-5) were done.The serum leptin and 5-HT levels were determined.Then the trial group were given sertraline hydrochloride for 8 weeks,while the control group were not given any medicine treatment in this period.Reassessment was done after 8 weeks.Results At the baseline,the leptin level in the trial group was obviously higher than the control group(P ＜ 0.05),while 5-HT level in the trial group was far lower than the control group(P ＜0.05).After 8 weeks,the leptin level of the trial group dropped and the difference had no statistical significance with that of the control group(P ＞0.05).5-HT level of the trial group rose to the level very close to that of the control group after the treatment.Conclusion The high level of serum leptin and low level of serum 5-HT were the meaningful biological indicators for PE,which can potentially be applied in PE diagnosis.