CAJ | 학술논문

目的了解乳腺癌内分泌治疗的依从性,分析影响内分泌治疗正确率的相关因素.方法对2006年6月至2008年6月在江苏省肿瘤医院住院治疗的379例激素受体阳性乳腺癌患者进行规范的电话随访,记录内分泌治疗完成情况,对成功随访病例进行依从性相关因素分析.结果 85.0％(322/379)成功随访,其中4.7％(15/322)完全未接受内分泌治疗,13.4％ (43/322)院外服用一段时间后自行停药,4.3％(14/322)无规律间断服药,250例规律完成了5年的口服内分泌治疗,治疗正确率为77.6％ (250/322).定量资料采用t检验和单因素方差分析发现,患者停药高峰主要集中在初始服药2个月内和2年内,分别占39.5％和48.8％;停药人群与患者所从事职业和受教育程度表现出相关性(初中以上及以下学历人群停药率分别为29.4％ vs 19.8％,P＜0.001),停药原因主要为对副作用的过度担心和难以坚持长期服药.结论内分泌治疗对激素受体阳性患者疗效肯定,已作为乳腺癌的常规治疗手段应用于临床,但由于治疗时间长、院外服药缺乏监管,使得内分泌治疗的正确率和依从性较低,很大程度降低了乳腺癌治疗疗效.如何对行内分泌治疗的患者进行科学管理,提高治疗依从性和疗效,值得医务人员探讨.
목적 료해유선암내분비치료적의종성,분석영향내분비치료정학솔적상관인소.방법 대2006년6월지2008년6월재강소성종류의원주원치료적379례격소수체양성유선암환자진행규범적전화수방,기록내분비치료완성정황,대성공수방병례진행의종성상관인소분석.결과 85.0％(322/379)성공수방,기중4.7％(15/322)완전미접수내분비치료,13.4％ (43/322)원외복용일단시간후자행정약,4.3％(14/322)무규률간단복약,250례규률완성료5년적구복내분비치료,치료정학솔위77.6％ (250/322).정량자료채용t검험화단인소방차분석발현,환자정약고봉주요집중재초시복약2개월내화2년내,분별점39.5％화48.8％;정약인군여환자소종사직업화수교육정도표현출상관성(초중이상급이하학력인군정약솔분별위29.4％ vs 19.8％,P＜0.001),정약원인주요위대부작용적과도담심화난이견지장기복약.결론 내분비치료대격소수체양성환자료효긍정,이작위유선암적상규치료수단응용우림상,단유우치료시간장、원외복약결핍감관,사득내분비치료적정학솔화의종성교저,흔대정도강저료유선암치료료효.여하대행내분비치료적환자진행과학관리,제고치료의종성화료효,치득의무인원탐토.
Objective To investigate the compliance with endocrine therapy(ET) and assess the factors associated with treatment accuracy for breast cancer.Methods 379 patients with hormone receptor-positive breast cancer undergoing complete treatment from Jun.2006 to Jun.2008 in Jiangsu Cancer Hospital were followed up.Factors related to compliance were analyzed.Results Among the 322 (85.0％) patients successfully interviewed,15 (4.7％) patients did not receive ET,43 (13.4％) patients stopped taking drugs after discharge,14 (4.3％)patients had intermittent ET,and the rest 250 patients obeyed 5-year oral ET regularly.The treatment accuracy was 77.6％ (250/332).We found that majority of withdraw occurred within 2 months and within 2 years,accounting for 39.5％ and 48.8％,respectively.Job and education status were relevant to these patients.Moreover,too much concern of adverse drug effects and difficulty of long-term medication were the main reasons to noncompliance.Conclusions ET is effective in hormone receptor-positive breast cancer patients and has been used as a conventional therapy.However,due to the long therapeutic period and lack of medical supervision after discharge,its treatment accuracy and compliances are becoming low,resulting in decreased efficiency.It is therefore necessary to investigate such patients' management to improve the compliance and treatment accuracy of ET.