中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2014年
5期
365-368
,共4页
徐雅莉%孟云霄%高云周%孙强
徐雅莉%孟雲霄%高雲週%孫彊
서아리%맹운소%고운주%손강
乳腺癌%保乳手术%腺体退化
乳腺癌%保乳手術%腺體退化
유선암%보유수술%선체퇴화
Breast cancer%Breast conservation surgery%Lobuli involution
目的 明确乳腺癌旁腺体退化程度及乳腺内不同部位腺体退化一致性.方法 选择2010年12月1日至2011年12月1日北京协和医院乳腺外科乳腺癌保乳改良根治术22例,测量88张HE染色切片乳腺小叶面积及小叶内腺泡数量,评估乳腺小叶退化程度.应用两变量相关分析考察乳腺小叶面积和小叶内腺泡数量间相关性;应用方差分析、列联表分析和信度分析考察不同位置腺体退化程度一致性(P＜0.05).结果 乳腺小叶平均面积(90 248.5±56 909.4) μm2,每个小叶平均含腺泡(25.68±18.86)个,乳腺小叶面积和小叶内腺泡数量具有显著相关性(Pearson r=0.78,P＜0.01).乳腺癌保乳改良根治术患者癌旁腺体退化程度具有一致性(方差分析小叶面积19例无差异,小叶面积/腺泡数量18例无差异;Kappa系数=0.65;组内相关系数ICC=0.73).结论 乳腺癌旁腺体退化不全,表现为乳腺小叶面积大及腺泡数量多,且2者具有相关性.乳腺癌旁不同位置腺体退化程度基本一致,单点退化程度能代表全乳腺情况.
目的 明確乳腺癌徬腺體退化程度及乳腺內不同部位腺體退化一緻性.方法 選擇2010年12月1日至2011年12月1日北京協和醫院乳腺外科乳腺癌保乳改良根治術22例,測量88張HE染色切片乳腺小葉麵積及小葉內腺泡數量,評估乳腺小葉退化程度.應用兩變量相關分析攷察乳腺小葉麵積和小葉內腺泡數量間相關性;應用方差分析、列聯錶分析和信度分析攷察不同位置腺體退化程度一緻性(P＜0.05).結果 乳腺小葉平均麵積(90 248.5±56 909.4) μm2,每箇小葉平均含腺泡(25.68±18.86)箇,乳腺小葉麵積和小葉內腺泡數量具有顯著相關性(Pearson r=0.78,P＜0.01).乳腺癌保乳改良根治術患者癌徬腺體退化程度具有一緻性(方差分析小葉麵積19例無差異,小葉麵積/腺泡數量18例無差異;Kappa繫數=0.65;組內相關繫數ICC=0.73).結論 乳腺癌徬腺體退化不全,錶現為乳腺小葉麵積大及腺泡數量多,且2者具有相關性.乳腺癌徬不同位置腺體退化程度基本一緻,單點退化程度能代錶全乳腺情況.
목적 명학유선암방선체퇴화정도급유선내불동부위선체퇴화일치성.방법 선택2010년12월1일지2011년12월1일북경협화의원유선외과유선암보유개량근치술22례,측량88장HE염색절편유선소협면적급소협내선포수량,평고유선소협퇴화정도.응용량변량상관분석고찰유선소협면적화소협내선포수량간상관성;응용방차분석、렬련표분석화신도분석고찰불동위치선체퇴화정도일치성(P＜0.05).결과 유선소협평균면적(90 248.5±56 909.4) μm2,매개소협평균함선포(25.68±18.86)개,유선소협면적화소협내선포수량구유현저상관성(Pearson r=0.78,P＜0.01).유선암보유개량근치술환자암방선체퇴화정도구유일치성(방차분석소협면적19례무차이,소협면적/선포수량18례무차이;Kappa계수=0.65;조내상관계수ICC=0.73).결론 유선암방선체퇴화불전,표현위유선소협면적대급선포수량다,차2자구유상관성.유선암방불동위치선체퇴화정도기본일치,단점퇴화정도능대표전유선정황.
Objective To study lobular involution of tissues around breast tumor,and to assess the consistency of lobular involution of tissues from different parts of the breast.Methods 22 patients receiving breast conservation surgery in Breast Surgery Department of Peking Union Medical College Hospital from Dec.1 st,2010to Dec.1 st,2011 were collected.88 pieces of HE staining were measured in terms of lobular area and number of acini per lobular,and lobular involution was evaluated.Bivatiate correlation analysis was applied to explore correlation between lobular area and acini per lobular.ANOVA,crosstabs and reliability analysis were applied to explore involution consistency of different parts of breast (P ＜ 0.05).Results The average area of lobuli was (90 248.5 +56 909.4) μm2 and the number of acini was 25.68 ± 18.86 per lobular.The lobular area and number of acini were correlated with each other significantly(Pearson r =0.78,P ＜ 0.01).Involution status of different parts of breast had good consistency(for lobular area 19 cases showed no difference in ANOVA analysis and for lobular area/number of acini 18 cases showed no difference; Kappa coefficient =0.65; ICC =0.73).Conelusions Lobuli around breast tumor have comparatively poor involution,with big lobuli and large number of acini,which are correlated with each other.Involution status of different parts of a breast has good consistency.Biopsy from one site to evaluate involution extent of the whole breast is practicable.
