CAJ | 학술논문

胶质细胞源性神经营养因子(GDNF)是一类调节肠神经系统存活、分化、定植及损伤修复的蛋白因子,在小儿先天性巨结肠、肛门直肠畸形等肠神经系统发育异常疾病中的研究已得到证实,但其具体调控机制不详;有研究发现GDNF/GFRa1/RET和GDNF/GFRa1/ NCAM通路可能参与肠神经系统发育与成熟,它们的异常将影响肠神经干细胞的分化、增殖及移行,引起肠神经元解剖结构和功能的异常,导致疾病发生.
효질세포원성신경영양인자(GDNF)시일류조절장신경계통존활、분화、정식급손상수복적단백인자,재소인선천성거결장、항문직장기형등장신경계통발육이상질병중적연구이득도증실,단기구체조공궤제불상;유연구발현GDNF/GFRa1/RET화GDNF/GFRa1/ NCAM통로가능삼여장신경계통발육여성숙,타문적이상장영향장신경간세포적분화、증식급이행,인기장신경원해부결구화공능적이상,도치질병발생.
Glial cell line-derived neurotrophic factor(GDNF) is a kind of protein factor which can regulate the enteric nervous system in survival,differentiation,colonization and injury repair.It has been confirmed in the disorders of the enteric nervous system,such as hirschsprung and anorectal malformations,but the specific mechanism in regulation of this factor is still unknown.Studies have found that GDNF/GFRa1/RET and GDNF/GFRa1 / NCAM pathway may be involved in the growth and maturation of the enteric nervous system,the disorders of those pathways above may lead to diseases by affecting the differentiation,proliferation and migration of intestinal neural stem cells,causing dysfunctions in the anatomical structure and function of the intestinal neurons.