中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2014年
10期
751-753
,共3页
张琳%王淮燕%梅涛%杨利民%史烨%虞斌
張琳%王淮燕%梅濤%楊利民%史燁%虞斌
장림%왕회연%매도%양이민%사엽%우빈
巨细胞病毒%母乳%病毒载量%婴儿
巨細胞病毒%母乳%病毒載量%嬰兒
거세포병독%모유%병독재량%영인
Cytomegalovirus%Breast milk%Viral load%Infant
目的 对先天性巨细胞病毒(CMV)感染的新生儿进行随访监测,探讨母乳喂养对CMV载量变化的影响.方法 采集2010年11月至2012年2月在常州市妇幼保健院山生的新生儿唾液进行CMV感染筛查,排除早产、严重感染性疾病或畸形等,对阳性感染且.无症状的足月新生儿根据母亲自主选择分成人工喂养组及母乳喂养组,随访至6个月,分别在出生1个月内、3个月、6个月采集唾液及母乳,采取实时荧光定量PCR法检测CMV-DNA的载量变化,同时行体格检查、头颅B超检查、耳声发射听力筛查、肝功能、血常规分析等检查.结果 30例婴儿在随访的6个月中均末发现有CMV感染性疾病的表现.人工喂养组与母乳喂养组婴儿在出生1个月内、3个月、6个月唾液巨细胞DNA载量末见明显变化(t=2.832、3.161、3.475,P均＞0.05).母乳喂养组乳汁在山生1个月内、3个月、6个月CMV-DNA载量分别为3.125×103±2.017×102、2.688×103±2.251×102、3.016×103 ±2.613×102,三者比较差异无统计学意义(F=1.725,P=0.667).头颅B超检查、耳声发射听力筛查、肝功能、血常规分析等检查末见明显异常.结论 CMV感染的足月无症状新生儿,即便母乳中CMV 阳性,继续母乳喂养后婴儿体内的病毒载量也不会增加,也末发现继发性的症状感染.
目的 對先天性巨細胞病毒(CMV)感染的新生兒進行隨訪鑑測,探討母乳餵養對CMV載量變化的影響.方法 採集2010年11月至2012年2月在常州市婦幼保健院山生的新生兒唾液進行CMV感染篩查,排除早產、嚴重感染性疾病或畸形等,對暘性感染且.無癥狀的足月新生兒根據母親自主選擇分成人工餵養組及母乳餵養組,隨訪至6箇月,分彆在齣生1箇月內、3箇月、6箇月採集唾液及母乳,採取實時熒光定量PCR法檢測CMV-DNA的載量變化,同時行體格檢查、頭顱B超檢查、耳聲髮射聽力篩查、肝功能、血常規分析等檢查.結果 30例嬰兒在隨訪的6箇月中均末髮現有CMV感染性疾病的錶現.人工餵養組與母乳餵養組嬰兒在齣生1箇月內、3箇月、6箇月唾液巨細胞DNA載量末見明顯變化(t=2.832、3.161、3.475,P均＞0.05).母乳餵養組乳汁在山生1箇月內、3箇月、6箇月CMV-DNA載量分彆為3.125×103±2.017×102、2.688×103±2.251×102、3.016×103 ±2.613×102,三者比較差異無統計學意義(F=1.725,P=0.667).頭顱B超檢查、耳聲髮射聽力篩查、肝功能、血常規分析等檢查末見明顯異常.結論 CMV感染的足月無癥狀新生兒,即便母乳中CMV 暘性,繼續母乳餵養後嬰兒體內的病毒載量也不會增加,也末髮現繼髮性的癥狀感染.
목적 대선천성거세포병독(CMV)감염적신생인진행수방감측,탐토모유위양대CMV재량변화적영향.방법 채집2010년11월지2012년2월재상주시부유보건원산생적신생인타액진행CMV감염사사,배제조산、엄중감염성질병혹기형등,대양성감염차.무증상적족월신생인근거모친자주선택분성인공위양조급모유위양조,수방지6개월,분별재출생1개월내、3개월、6개월채집타액급모유,채취실시형광정량PCR법검측CMV-DNA적재량변화,동시행체격검사、두로B초검사、이성발사은력사사、간공능、혈상규분석등검사.결과 30례영인재수방적6개월중균말발현유CMV감염성질병적표현.인공위양조여모유위양조영인재출생1개월내、3개월、6개월타액거세포DNA재량말견명현변화(t=2.832、3.161、3.475,P균＞0.05).모유위양조유즙재산생1개월내、3개월、6개월CMV-DNA재량분별위3.125×103±2.017×102、2.688×103±2.251×102、3.016×103 ±2.613×102,삼자비교차이무통계학의의(F=1.725,P=0.667).두로B초검사、이성발사은력사사、간공능、혈상규분석등검사말견명현이상.결론 CMV감염적족월무증상신생인,즉편모유중CMV 양성,계속모유위양후영인체내적병독재량야불회증가,야말발현계발성적증상감염.
Objective Follow-up monitoring was carried out in infants infected with cytomegalovirus (CMV) so as to find out whether breastfeeding could bring about changes of CMV viral load.Methods Saliva of the neonates born in Changzhou Maternal and Child Health Hospital from Nov.2010 to Feb.2012,was collected for CMV screening.Premature infants,or the infants with seriously infectious diseases and deformities were excluded,such as severe intrauterine infection,congenital immune deficiency disease and so on.The full-term infants with aymptomatic infection were divided into the artificial feeding group and the breastfeeding group,and followed up for 6 months.During the 1st,the 3rd and the 6th month after their birth,their saliva and their mother's breast milk were collected.The method of realtime fluorescent quantitative PCR was adopted to test the changes in the viral load of CMV-DNA in the saliva and breast milk.Meanwhile,head B-ultrasound test,otoacoustic emission hearing screening,liver function test,blood routine analysis and so on were performed.Results Among infants from both artificial feeding group and breastfeeding group,during the 1 st,the 3 rd and the 6th month after birth,no significant changes in the DNA viral load of saliva and breast milk cytomegalovirus were found (t =2.832,3.161,3.475,all P ＞ 0.05).And in breastfeeding group,the cytomegalovirus DNA viral load in breast milk were 3.125 × 103 ±2.017 × 102 (the 1st month),2.688 × 103 ±2.251 × 102 (the 3rd month),3.016 × 103 ±2.613 × 102 (the 6th rmonth),also no significance during the time (F =1.725,P =0.667).Meanwhile,the head B-ultrasound,otoacoustic emission hearing screening,liver function test,blood routine analysis,etc showed no clinical significance (F =1.725,P =0.667).Conclusions In the CMV-infected neonates,even if CMV in breast milk is tested to be positive,breastfeeding can continue without causing secondary symptoms of infection.
