CAJ | 학술논문

围生期多种因素可导致胎儿或新生儿不同程度的缺氧性脑损伤,多见于围生期窒息.缺氧引起脑损伤的机制一直未能充分阐明,且目前尚无有效的药物及治疗方法改善围生期缺氧所致的脑损伤.现就近年来关于斑马鱼作为模式动物研究缺氧性脑损伤的研究进展作一综述,主要从斑马鱼缺氧性脑损伤模型的解剖学和行为学基础、建模方法、研究策略,并结合其在神经营养药物筛查方面的优势进行分析,对斑马鱼研究缺氧性脑损伤的研究前景进行了展望,为研究新生儿缺氧缺血性脑病的治疗方案提供了新思路.
위생기다충인소가도치태인혹신생인불동정도적결양성뇌손상,다견우위생기질식.결양인기뇌손상적궤제일직미능충분천명,차목전상무유효적약물급치료방법개선위생기결양소치적뇌손상.현취근년래관우반마어작위모식동물연구결양성뇌손상적연구진전작일종술,주요종반마어결양성뇌손상모형적해부학화행위학기출、건모방법、연구책략,병결합기재신경영양약물사사방면적우세진행분석,대반마어연구결양성뇌손상적연구전경진행료전망,위연구신생인결양결혈성뇌병적치료방안제공료신사로.
Many factors,especially perinatal asphyxia,can lead to varying degrees of hypoxia brain injury in fetus or newborns within perinatal period.So far,the mechanisms of neonatal cerebral damage caused by hypoxia during the perinatal period have not been clearly demonstrated,and there have no effective drugs or therapeutic methods to improve hypoxia-induced cerebral damage.This review focuses on the recent progress of zebrafish as a model organism of using in research of hypoxia brain injury,including the anatomic and behavior basis,model making,research strategies and the advantages of neurotrophic drug screening.The application of zebrish in the research of neonatal hypoxic brain injury is promising,and may provide a new tool as research in finding out the therapy strategies of hypoxic-ischemic encephalopathy.