CAJ | 학술논문

目的评价急性白血病患儿在造血干细胞移植(HSCT)治疗后的生存质量;分析影响HSCT患儿生存质量的因素.方法选取60例在北京2个血液中心接受HSCT治疗,移植成功并存活4个月以上的2～18岁的急性白血病患儿作为研究对象.患儿家长及8～18岁患儿完成PedsQLTM癌症模块3.0中文版,并从病例中收集患儿的临床资料,对患儿的生存质量进行测评、分析.结果 49例患儿家长及32例患儿参与并完成量表.49例患儿中男34例(69.4％),女15例(30.6％);年龄(9.94±4.24)岁;急性淋巴细胞白血病28例(57.1％),急性髓细胞白血病19例(38.8％),急性混合性白血病2例(4.1％);复发后缓解患儿16例(32.7％),首次缓解患儿33例(67.3％).各年龄段患儿在HSCT 4个月后总体生存质量可达到中等偏上,平均分为68 ～ 75分(总分100分);移植前状态(OR=0.197,P=0.021)及母亲文化程度(OR=3.932,P=0.043)是HSCT患儿生存质量的影响因素:移植前为复发后缓解或母亲文化程度低的患儿生存质量更差;性别、诊断、供者来源、轻度慢性移植物抗宿主病、父母亲工作情况、父亲文化程度、家庭所在区域对患儿生存质量的影响差异无统计学意义.结论 HSCT 4个月后患儿总体生存质量可达到中等偏上,影响HSCT患儿生存质量的因素包括HSCT前状态及母亲文化程度.
목적 평개급성백혈병환인재조혈간세포이식(HSCT)치료후적생존질량;분석영향HSCT환인생존질량적인소.방법 선취60례재북경2개혈액중심접수HSCT치료,이식성공병존활4개월이상적2～18세적급성백혈병환인작위연구대상.환인가장급8～18세환인완성PedsQLTM암증모괴3.0중문판,병종병례중수집환인적림상자료,대환인적생존질량진행측평、분석.결과 49례환인가장급32례환인삼여병완성량표.49례환인중남34례(69.4％),녀15례(30.6％);년령(9.94±4.24)세;급성림파세포백혈병28례(57.1％),급성수세포백혈병19례(38.8％),급성혼합성백혈병2례(4.1％);복발후완해환인16례(32.7％),수차완해환인33례(67.3％).각년령단환인재HSCT 4개월후총체생존질량가체도중등편상,평균분위68 ～ 75분(총분100분);이식전상태(OR=0.197,P=0.021)급모친문화정도(OR=3.932,P=0.043)시HSCT환인생존질량적영향인소:이식전위복발후완해혹모친문화정도저적환인생존질량경차;성별、진단、공자래원、경도만성이식물항숙주병、부모친공작정황、부친문화정도、가정소재구역대환인생존질량적영향차이무통계학의의.결론 HSCT 4개월후환인총체생존질량가체도중등편상,영향HSCT환인생존질량적인소포괄HSCT전상태급모친문화정도.
Objective To evaluate the quality of life of patients with pediatric acute leukemia post hematopoietic stem cell transplantation (HSCT) and to analyze the influential factors for patients' quality of life.Methods Sixty of acute leukemia patients from 2 to 18 years old received HSCT and attained more than 4 months survival were recruited from 2 hematology centers in Beijing.PedsQLTM Cancer Module 3.0 Chinese mandarin version was completed by both parents and 8-18 years old patients.Clinical data were extracted from medical records.The quality of life of patients was evaluated and analyzed.Results Forty-nine parents and 32 patients consented to participate and completed the questionnaires,with 34 boys (69.4％) and 15 girls (30.6％).The age of them was (9.94-±4.24)years old.The sample included 28 acute lymphoblastic leukemia patients (57.1％),19 acute myeloid leukemia patients (38.8％) and 2 acute mixed leukemia patients (4.1％); 16 second complete remission patients (32.7％) and 33 first remission patients (67.3％).The mean scores of overall quality of life after HSCT were 68-75 (out of 100),which was above the average.The disease status before transplantation (OR =0.197,P =0.021) and the education level of patient's mother (OR =3.932,P =0.043) were the influential factors for children's quality of life post HSCT:second complete remission status and the lower education level of mother resulted in worse quality of life.Neither gender,diagnosis,donor sources,slight graft versus host disease,parents' job,education level of father,nor home area influenced the quality of life significantly.Conclusions The overall quality of life of HSCT patients is above the average.The influential factors for patients' quality of life include the disease status before transplantation and the educational level of patients' mother.