CAJ | 학술논문

近年来肥胖相关性肾小球病的发病率持续增高.研究表明慢性炎症状态在肥胖相关性代谢功能障碍的发病中发挥关键作用.脂氧素A4是重要的抗感染介质,被誉为炎性反应的“终止信号”,可促进炎症恢复.现将肥胖相关性肾小球病与脂氧素A4的研究进展做一综述.
근년래비반상관성신소구병적발병솔지속증고.연구표명만성염증상태재비반상관성대사공능장애적발병중발휘관건작용.지양소A4시중요적항감염개질,피예위염성반응적“종지신호”,가촉진염증회복.현장비반상관성신소구병여지양소A4적연구진전주일종술.
The morbidity of obesity-related glomerulopathy(ORG) is on the increase in recent years.Studies have demonstrated that the chronic inflammation may play a key role in the pathogenesis of obesity related metabolic dysfunction.LipoxinA4 (LXA4) is an important anti-inflammatory lipid mediator,which is well known as the "stop signal" of the inflammatory reaction that can promote the resolution of inflammation.This review will provide a survey of recent advances on ORG and LXA4.