CAJ | 학술논문

儿童脓毒症/严重脓毒症是儿童重症监护室中一种常见且病死率较高的疾病;细胞因子的“瀑布式”级联反应是导致病情持续恶化的主要原因.持续血液净化治疗技术可利用吸附及滤过等原理清除炎性介质,能够重建免疫稳态、降低患儿病死率.但目前,持续血液净化高、低剂量疗效的结论不同,对不同剂量的选择存在争议.现从不同角度介绍血液净化高、低剂量的效果,分析不同效果的影响因素.
인동농독증/엄중농독증시인동중증감호실중일충상견차병사솔교고적질병;세포인자적“폭포식”급련반응시도치병정지속악화적주요원인.지속혈액정화치료기술가이용흡부급려과등원리청제염성개질,능구중건면역은태、강저환인병사솔.단목전,지속혈액정화고、저제량료효적결론불동,대불동제량적선택존재쟁의.현종불동각도개소혈액정화고、저제량적효과,분석불동효과적영향인소.
Spesis/severe sepsis remains a serious problem in pediatric intensive care unit.The mortality of sepsis/severe sepsis is still very high.The "waterfall" cascade reaction of cell factors is the main reason leading to the continued deterioration of the condition.Continuous blood purification technology can not only remove inflammatory mediators by adsorption and filtration function,but also improve the immune function,even reduce the mortality rate.But there is a controversial topic on the selection of the appropriate dose.This review not only introduces the effects of high-volume hemofiltration and low-volume hemofiltration from different aspects,but also analyses the influencing factors of different effects.