中国实用护理杂志
中國實用護理雜誌
중국실용호리잡지
CHINESE JOURNAL OF PRACTICAL NURSING
2014年
23期
9-11
,共3页
沈林生%王萍%肖灯科%张如燕%缪媛媛%郭雨露
瀋林生%王萍%肖燈科%張如燕%繆媛媛%郭雨露
침림생%왕평%초등과%장여연%무원원%곽우로
输液性静脉炎%甘露醇%动物模型%家兔
輸液性靜脈炎%甘露醇%動物模型%傢兔
수액성정맥염%감로순%동물모형%가토
Infusion phlebitis%Mannitol%Animal model%Rabbit
目的 探索合理构建甘露醇致家兔输液性静脉炎的制模参数.方法 以血管壁损伤、炎性细胞浸润、血栓形成的出现频率为指标,镜下观察和比较不同给药速率、病理取材时间及部位等各独立实验中20％甘露醇对兔耳缘静脉的病理损害.结果 兔耳缘静脉在给药速率5.0 ml/min、给药后24 h、注射点近心端1 cm处取材时的镜下病理损害最明显.结论 采用上述参数可建立较稳定的甘露醇致家兔输液性静脉炎模型.
目的 探索閤理構建甘露醇緻傢兔輸液性靜脈炎的製模參數.方法 以血管壁損傷、炎性細胞浸潤、血栓形成的齣現頻率為指標,鏡下觀察和比較不同給藥速率、病理取材時間及部位等各獨立實驗中20％甘露醇對兔耳緣靜脈的病理損害.結果 兔耳緣靜脈在給藥速率5.0 ml/min、給藥後24 h、註射點近心耑1 cm處取材時的鏡下病理損害最明顯.結論 採用上述參數可建立較穩定的甘露醇緻傢兔輸液性靜脈炎模型.
목적 탐색합리구건감로순치가토수액성정맥염적제모삼수.방법 이혈관벽손상、염성세포침윤、혈전형성적출현빈솔위지표,경하관찰화비교불동급약속솔、병리취재시간급부위등각독립실험중20％감로순대토이연정맥적병리손해.결과 토이연정맥재급약속솔5.0 ml/min、급약후24 h、주사점근심단1 cm처취재시적경하병리손해최명현.결론 채용상술삼수가건립교은정적감로순치가토수액성정맥염모형.
Objective To explore the reasonable experimental parameters on establishment of rabbit model of infusion phlebitis induced by mannitol.Methods New Zealand rabbits were injected with 20％ mannitol,then pathological lesion of rabbit auricular vein induced by different infusion velocity,different sampling time and sites were observed under microscope with vascular injury,inflammatory cell infiltration,frequency of thrombokinesis as indexes.Results The three indexes were the highest and the most obvious characteristics of infusion phlebitis were noted at the following experimental conditions:5.0 ml/min (infusion velocity),sampling time at 24h after administration and sampling site at 1cm region in front of the catheter tip.Conclusions Rabbit model of infusion phlebitis induced by mannitol can be set up more stable by using these parameters.
