CAJ | 학술논문

目的观察免疫吸附治疗重症系统性红斑狼疮的疗效与不良反应,探讨血浆免疫吸附的护理.方法收集2009年5月至2012年8月78例重症系统性红斑狼疮患者作为研究对象,将所有患者随机分为治疗组和对照组,治疗组运用免疫吸附配合激素和免疫抑制剂治疗,对照组予以激素和免疫抑制剂治疗.比较两组患者治疗前后系统性红斑狼疮AI评分及相关化验指标的差异.结果治疗后治疗组各项指标均优于对照组,两组比较,差异有统计学意义(P＜0.05)；如治疗后治疗组白细胞为(6.4±2.3)×109/L,高于对照组的(5.1±2.5)×109/L,治疗组血沉为(20±15)g/L,高于对照组的(17±2.3)g/L,治疗组其余各项指标均与对照组比较,差异有统计学意义(P＜0.05).结论严格的治疗前准备、正确操作及密切的观察护理,能提高免疫吸附治疗的安全性和耐受性.
목적 관찰면역흡부치료중증계통성홍반랑창적료효여불량반응,탐토혈장면역흡부적호리.방법 수집2009년5월지2012년8월78례중증계통성홍반랑창환자작위연구대상,장소유환자수궤분위치료조화대조조,치료조운용면역흡부배합격소화면역억제제치료,대조조여이격소화면역억제제치료.비교량조환자치료전후계통성홍반랑창AI평분급상관화험지표적차이.결과 치료후치료조각항지표균우우대조조,량조비교,차이유통계학의의(P＜0.05)；여치료후치료조백세포위(6.4±2.3)×109/L,고우대조조적(5.1±2.5)×109/L,치료조혈침위(20±15)g/L,고우대조조적(17±2.3)g/L,치료조기여각항지표균여대조조비교,차이유통계학의의(P＜0.05).결론 엄격적치료전준비、정학조작급밀절적관찰호리,능제고면역흡부치료적안전성화내수성.
Objective To explore the effect and adverse reactions of immunoadsorption treatment on patients with sever systemic lupus erythematosus (SLE) and discuss related nursing.Methods Seventy-eight severe SLE patients from May 2009 to August 2012 were chosen and randomly divided into the treatment group and the control group.The treatment group was treated with immuno-adsorption combined with hormone and immunosuppressant,while the control group was treated with only hormone immunosuppressant.SLEDAI score and laboratorial indexes were compared between two groups before and after the treatment.Results All indexes were better in the treatment group than in the control group after treatment,with statistically significant difference (P＜0.05).The count of white blood cell and blood sedimentation was respectively(6.4 ±2.3) × 109/L and (20 ± 15) g/L in the treatment group,both higher than (5.1 ± 2.5) x 109/L and (17 ± 2.3) g/L in the control group.Conclusions Strict pre-treatment preparation,proper operation and careful nursing can improve the safety and the tolerability of immunoadsorption treatment.