中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2012年
4期
314-316
,共3页
付玉梅%杨晓仪%梁惠芬%朱寿萍
付玉梅%楊曉儀%樑惠芬%硃壽萍
부옥매%양효의%량혜분%주수평
β内酰胺酶类%假单胞菌,铜绿%亚胺培南%抗药性,多药
β內酰胺酶類%假單胞菌,銅綠%亞胺培南%抗藥性,多藥
β내선알매류%가단포균,동록%아알배남%항약성,다약
beta-Lactamases%Pseudomonas aeruginosa%Imipenem%Drug resistance,multiple
目的 了解多重耐药铜绿假单胞菌(M RPA)的社区感染情况及产金属β内酰胺酶(MBL)情况.方法 2011年1月至12月在广州市多个社区医院收集分离出MRPA 54株.采用MicroScan Walk Away 40S1全自动细菌鉴定与药敏检测系统检测其对亚胺培南等11种抗菌药物的耐药性,比较亚胺培南耐药铜绿假单胞菌与亚胺培南敏感铜绿假单胞菌对常用9种抗菌药物的耐药率.改良三维实验分析亚胺培南耐药铜绿假单胞菌产MBL情况.结果 54株MRPA中有29株对亚胺培南耐药,占53.7％( 29/54).三维试验显示有9株亚胺培南耐药铜绿假单胞菌产MBL,占31.0％( 9/29).亚胺培南耐药铜绿假单胞菌对常用7种抗菌药物的耐药率显著高于亚胺培南敏感铜绿假单胞菌(头孢他啶:65.5％比36.0％;头孢噻肟:89.7％比44.0％;头孢曲松:100.0％比52.0％:氨曲南:72.4％比36.0％,氧氟沙星:70.0％比32.0％;哌拉西林-他唑巴坦:58.6％比16.0％;阿米卡星:62.1％比32.0％,均P＜0.05).结论 社区医疗机构临床分离MRPA 产MBL的比率较高.
目的 瞭解多重耐藥銅綠假單胞菌(M RPA)的社區感染情況及產金屬β內酰胺酶(MBL)情況.方法 2011年1月至12月在廣州市多箇社區醫院收集分離齣MRPA 54株.採用MicroScan Walk Away 40S1全自動細菌鑒定與藥敏檢測繫統檢測其對亞胺培南等11種抗菌藥物的耐藥性,比較亞胺培南耐藥銅綠假單胞菌與亞胺培南敏感銅綠假單胞菌對常用9種抗菌藥物的耐藥率.改良三維實驗分析亞胺培南耐藥銅綠假單胞菌產MBL情況.結果 54株MRPA中有29株對亞胺培南耐藥,佔53.7％( 29/54).三維試驗顯示有9株亞胺培南耐藥銅綠假單胞菌產MBL,佔31.0％( 9/29).亞胺培南耐藥銅綠假單胞菌對常用7種抗菌藥物的耐藥率顯著高于亞胺培南敏感銅綠假單胞菌(頭孢他啶:65.5％比36.0％;頭孢噻肟:89.7％比44.0％;頭孢麯鬆:100.0％比52.0％:氨麯南:72.4％比36.0％,氧氟沙星:70.0％比32.0％;哌拉西林-他唑巴坦:58.6％比16.0％;阿米卡星:62.1％比32.0％,均P＜0.05).結論 社區醫療機構臨床分離MRPA 產MBL的比率較高.
목적 료해다중내약동록가단포균(M RPA)적사구감염정황급산금속β내선알매(MBL)정황.방법 2011년1월지12월재엄주시다개사구의원수집분리출MRPA 54주.채용MicroScan Walk Away 40S1전자동세균감정여약민검측계통검측기대아알배남등11충항균약물적내약성,비교아알배남내약동록가단포균여아알배남민감동록가단포균대상용9충항균약물적내약솔.개량삼유실험분석아알배남내약동록가단포균산MBL정황.결과 54주MRPA중유29주대아알배남내약,점53.7％( 29/54).삼유시험현시유9주아알배남내약동록가단포균산MBL,점31.0％( 9/29).아알배남내약동록가단포균대상용7충항균약물적내약솔현저고우아알배남민감동록가단포균(두포타정:65.5％비36.0％;두포새우:89.7％비44.0％;두포곡송:100.0％비52.0％:안곡남:72.4％비36.0％,양불사성:70.0％비32.0％;고랍서림-타서파탄:58.6％비16.0％;아미잡성:62.1％비32.0％,균P＜0.05).결론 사구의료궤구림상분리MRPA 산MBL적비솔교고.
Objective To investigate the infection status and metallo-β-lactamase (MBL) production of multi-drug resistant Pseudomonas aeruginosa (MRPA) in community medical institutions.Methods A total of54 MRPA trains were isolated fron multiple community medical institutions in Guangzhou between January and December 2011.The drug-resislance to 11 types of antibioties,including imipenem,was tested by using MicroScan Walk Away 40S1 automatie bbaecteria identiffication and drug sensitivity testing system.The resistance of imipenem-sensitive and -resistant Pseudomonas aeruginosa to nine common antibioties was compared.Production of MBL in imipenem-resistant Pseudomonas aeruginosa was analyzed via modified three-dimensionalexperiment.Results Of 54 MRPA strains,29(53.7％) were resistant to imipenem.There were a total of 9 imipenem-resistant Pseudomonas aeruginosa strains (9/29,31.0％ ) that produced MBL,as revealed by three-dimensional experiment.lmipenem-resistant Pseudomonas aeruginosa yielded higher resistance rate to seven types of common antibiotics (ceftazidime:65.5％ vs 36.0％ ; cefotaxime:89.7％ vs 44.0％ ; ceftriaxone:100.0％ vs 52.0％; aztreonam:72.4％ vs 36.0％; ofloxacin:70.0％ vs 32.0％; piperacillin-tazobactam:58.6％ vs 16.0％ ;amikaein:62.1％ vs 32.0％,all P＜0.05) as compared with imipenem-sensitive Pseudomonas aeruginosa.Conclusion The ratio of MBL-production from clinical isolated MRPA is higher in community medical institutions.
