中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2013年
3期
224-226
,共3页
李宝琴%秦青%王立芹%刘璠%燕启江
李寶琴%秦青%王立芹%劉璠%燕啟江
리보금%진청%왕립근%류번%연계강
精神分裂症%半胱氨酸%脂蛋白(A)%甲状腺激素
精神分裂癥%半胱氨痠%脂蛋白(A)%甲狀腺激素
정신분렬증%반광안산%지단백(A)%갑상선격소
Schizophrenia%Cysteine%Lipoprotein(a)%Thyroid hormone
目的 探讨利培酮对精神分裂症患者血清同型半胱氨酸、脂蛋白a、甲状腺激素水平影响.方法 选择首发精神分裂症患者50例,服用利培酮治疗前及8周后分别抽血检测血清同型半胱氨酸、脂蛋白a、甲状腺激素水平.结果 治疗前FT3 (3.30±0.60) ng/L、T4(9.25±2.25) mg/L;治疗后FT3(3.10±0.60)ng/L、T4(8.54± 1.71) mg/L,结果均降低,差异有统计学意义(P＜0.05).FT4、T3、TSH、同型半胱氨酸、脂蛋白a治疗前后差异无统计学意义(P＞0.05).结论 长期服用抗精神分裂症药物患者需监测甲状腺激素水平.
目的 探討利培酮對精神分裂癥患者血清同型半胱氨痠、脂蛋白a、甲狀腺激素水平影響.方法 選擇首髮精神分裂癥患者50例,服用利培酮治療前及8週後分彆抽血檢測血清同型半胱氨痠、脂蛋白a、甲狀腺激素水平.結果 治療前FT3 (3.30±0.60) ng/L、T4(9.25±2.25) mg/L;治療後FT3(3.10±0.60)ng/L、T4(8.54± 1.71) mg/L,結果均降低,差異有統計學意義(P＜0.05).FT4、T3、TSH、同型半胱氨痠、脂蛋白a治療前後差異無統計學意義(P＞0.05).結論 長期服用抗精神分裂癥藥物患者需鑑測甲狀腺激素水平.
목적 탐토리배동대정신분렬증환자혈청동형반광안산、지단백a、갑상선격소수평영향.방법 선택수발정신분렬증환자50례,복용리배동치료전급8주후분별추혈검측혈청동형반광안산、지단백a、갑상선격소수평.결과 치료전FT3 (3.30±0.60) ng/L、T4(9.25±2.25) mg/L;치료후FT3(3.10±0.60)ng/L、T4(8.54± 1.71) mg/L,결과균강저,차이유통계학의의(P＜0.05).FT4、T3、TSH、동형반광안산、지단백a치료전후차이무통계학의의(P＞0.05).결론 장기복용항정신분렬증약물환자수감측갑상선격소수평.
Objective To study the effects of risperidone on serum homocysteine,lipoprotein a and thyroid hormone in patients with initial episodic schizophrenia.Methods Fifty patients with initial episodic schizophrenia treated with a 8-week course of risperidone were subjected to measurement of serum homocysteine,lipoprotein a and thyroid hormone prior to and following the treatment.Results Treatment of risperidone resulted in a marked reduction in FT3 [(3.30±0.60) ng/L vs (3.10±0.60) ng/L] and T4[(9.23± 2.25) mg/L vs (8.54± 1.71) mg/L,(both P＜0.05)].The changes in FT4,T3,TSH,homocysteine and lipoproteina from baseline were unremarkable (all P＞0.05).Conclusion Long-term administration of antipsvchotic drugs necessitates monitoring of thyroid hormones.
