中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2013年
3期
233-236
,共4页
杨薪%钟向红%李斌%黄兆琦
楊薪%鐘嚮紅%李斌%黃兆琦
양신%종향홍%리빈%황조기
高血压%颈动脉疾病%动脉粥样硬化%血基质金属蛋白酶9%钠盐
高血壓%頸動脈疾病%動脈粥樣硬化%血基質金屬蛋白酶9%鈉鹽
고혈압%경동맥질병%동맥죽양경화%혈기질금속단백매9%납염
Hypertension%Carotid artery disease%Atherosclerosis%Matrix metalloproteinase-9%Sodium
目的 探讨原发性高血压成人尿钠排泄量与颈动脉粥样硬化及血基质金属蛋白酶9的关系.方法 选择成人原发性高血压117例,通过24 h尿钠排泄量测定钠盐摄入量,将入选人群分为低盐组(n=30),低中盐组(n=28),中高盐组(n=27),高盐组(n=32).测量颈动脉内膜中层厚度(IMT)值,采用酶联免疫吸附法检测血基质金属蛋白酶9(MMP-9)水平.用多元逐步线性回归分析法分析24h尿钠排泄量、年龄、性别、血压、脉率、BMI、胆固醇、三酰甘油、血糖对IMT值的影响.对MMP-9与尿钠排泄量及IMT值进行相关性分析.结果 4组患者的收缩压、舒张压、IMT值,随24 h尿钠排泄量的增加而增高(P＜0.05).多元逐步线性回归分析结果显示24 h尿钠排泄量增高是IMT增加的独立危险因素(回归系数0.021,P＜0.05).MMP-9与尿钠排泄量存在正相关性(r=0.33,P＜0.05).结论 高血压患者高钠饮食可能有独立于血压之外的影响,促进动脉粥样硬化的形成.MMP-9的活性可能发挥了作用.
目的 探討原髮性高血壓成人尿鈉排洩量與頸動脈粥樣硬化及血基質金屬蛋白酶9的關繫.方法 選擇成人原髮性高血壓117例,通過24 h尿鈉排洩量測定鈉鹽攝入量,將入選人群分為低鹽組(n=30),低中鹽組(n=28),中高鹽組(n=27),高鹽組(n=32).測量頸動脈內膜中層厚度(IMT)值,採用酶聯免疫吸附法檢測血基質金屬蛋白酶9(MMP-9)水平.用多元逐步線性迴歸分析法分析24h尿鈉排洩量、年齡、性彆、血壓、脈率、BMI、膽固醇、三酰甘油、血糖對IMT值的影響.對MMP-9與尿鈉排洩量及IMT值進行相關性分析.結果 4組患者的收縮壓、舒張壓、IMT值,隨24 h尿鈉排洩量的增加而增高(P＜0.05).多元逐步線性迴歸分析結果顯示24 h尿鈉排洩量增高是IMT增加的獨立危險因素(迴歸繫數0.021,P＜0.05).MMP-9與尿鈉排洩量存在正相關性(r=0.33,P＜0.05).結論 高血壓患者高鈉飲食可能有獨立于血壓之外的影響,促進動脈粥樣硬化的形成.MMP-9的活性可能髮揮瞭作用.
목적 탐토원발성고혈압성인뇨납배설량여경동맥죽양경화급혈기질금속단백매9적관계.방법 선택성인원발성고혈압117례,통과24 h뇨납배설량측정납염섭입량,장입선인군분위저염조(n=30),저중염조(n=28),중고염조(n=27),고염조(n=32).측량경동맥내막중층후도(IMT)치,채용매련면역흡부법검측혈기질금속단백매9(MMP-9)수평.용다원축보선성회귀분석법분석24h뇨납배설량、년령、성별、혈압、맥솔、BMI、담고순、삼선감유、혈당대IMT치적영향.대MMP-9여뇨납배설량급IMT치진행상관성분석.결과 4조환자적수축압、서장압、IMT치,수24 h뇨납배설량적증가이증고(P＜0.05).다원축보선성회귀분석결과현시24 h뇨납배설량증고시IMT증가적독립위험인소(회귀계수0.021,P＜0.05).MMP-9여뇨납배설량존재정상관성(r=0.33,P＜0.05).결론 고혈압환자고납음식가능유독립우혈압지외적영향,촉진동맥죽양경화적형성.MMP-9적활성가능발휘료작용.
Objective To investigate the correlation between urinary sodium excretion and carotid atherosclerosis and serum matrix metalloproteinase-9 (MMP) in adults with essential hypertension.Methods A total of 117 adults with essential hypertension were enrolled in the study,and based on their 24-hour urinary sodium excretion,divided into low (n=30),moderate (n=30),moderate-to-high (n=30) and high sodium intake group (n=30),respectively.Intimal medium thickness (IMT) was examined by color Doppler ultrasonography,and serum MMP-9 was determined by enzyme-linked immunosorbent assay.Stepwise regression analysis was employed to evaluate the effects of 24-hour urinary sodium excretion,age,sex,blood pressure,pulse rate,body mass index,cholesterol,triglyceride and blood glucose on the level of IMT.The correlation between MMP-9 and urinary sodium excretion was also analyzed.Results Increased level of 24-hour urinary sodium excretion was associated with augmented systolic and diastolic blood pressure and IMT (all P＜0.05).The 24-hour urinary sodium excretion was,as suggested by stepwise regression analysis,the independent risk factor of increased IMT (regression coefficient 0.021,P＜0.05).MMP-9 was positively correlated with urinary sodium excretion (r=0.33,P＜0.05).Conclusion High sodium intake,may lead to increased incidence of carotid atherosclerosis independently of the blood pressure,and MMP-9 may play a role in the development.
