CAJ | 학술논문

目的自体骨髓间充质干细胞移植治疗早期脊髓损伤的近期疗效和安全性.方法 2008年1月至2011年1月本院收治早期脊髓损伤患者64例,其中干细胞移植组35例患者通过蛛网膜下隙注射方式行白体骨髓间充质干细胞移植,同期入院但未行干细胞移植患者29例作为对照组.分别于移植前,移植后1、3、6个月采用美国脊髓损伤协会(ASIA)制定的评分标准对两组患者运动、感觉功能进行评定.同期随访血常规、凝血机制、生化全项、肿瘤标记物.结果移植后1个月,两组患者运动、感觉功能都有不同程度恢复,且感觉功能恢复更为明显,各组间比较差异均无统计学意义(P＞0.05).移植后3个月,各组患者运动功能评分均有所提高,各组间比较差异均无统计学意义(P＞0.05).移植组患者感觉功能评分[(131.9±41.6)分]显著提高,与对照组[(108.3±36.4)分]比较差异有统计学意义(P＜0.05).移植后6个月,对照组患者运动、感觉功能评分均未出现明显提高;蛛网膜下隙移植组患者仍有明显恢复,与对照组比较差异有统计学意义(P＜0.05).随访各项检查结果均未出现明显异常.结论蛛网膜下隙注射途径进行自体骨髓间充质干细胞移植治疗早期脊髓损伤安全,近期疗效确切,但远期疗效及安全性尚待进一步观察.
목적 자체골수간충질간세포이식치료조기척수손상적근기료효화안전성.방법 2008년1월지2011년1월본원수치조기척수손상환자64례,기중간세포이식조35례환자통과주망막하극주사방식행백체골수간충질간세포이식,동기입원단미행간세포이식환자29례작위대조조.분별우이식전,이식후1、3、6개월채용미국척수손상협회(ASIA)제정적평분표준대량조환자운동、감각공능진행평정.동기수방혈상규、응혈궤제、생화전항、종류표기물.결과 이식후1개월,량조환자운동、감각공능도유불동정도회복,차감각공능회복경위명현,각조간비교차이균무통계학의의(P＞0.05).이식후3개월,각조환자운동공능평분균유소제고,각조간비교차이균무통계학의의(P＞0.05).이식조환자감각공능평분[(131.9±41.6)분]현저제고,여대조조[(108.3±36.4)분]비교차이유통계학의의(P＜0.05).이식후6개월,대조조환자운동、감각공능평분균미출현명현제고;주망막하극이식조환자잉유명현회복,여대조조비교차이유통계학의의(P＜0.05).수방각항검사결과균미출현명현이상.결론 주망막하극주사도경진행자체골수간충질간세포이식치료조기척수손상안전,근기료효학절,단원기료효급안전성상대진일보관찰.
Objective To observe the short-term efficacy and safety of autologous bone marrow mesenchymal stem cells transplantation on patients with early spinal cord injury.Methods A total of 64 patients of early spinal cord injury were collected from January 2008 to January 2011.The cases were divided into two groups:the transplantation group (n=35) treated by subarachnoid injection with autologous bone marrow mesenchymal stem cells,the control group (n=29) in the same period of hospitalization without transplantation.Two groups were evaluated with motor and sensory function according to the AISA score before transplantation and the first,the third,the sixth month after transplantation respectively.Meanwhile,blood routine,clotting function,biochemical items and tumor markers were also followed up.Results There was varying degree recovery of motor and sensory function in two groups at the first month after transplantation,and sensory function recovered obviously but no statistical differences were found between two groups.The score of motor function increased in both groups at the third month after transplantation,but still without statistical differences (P＞0.05).The score of sensory function of subarachnoid transplantation group (131.9±41.6) was significantly higher compared to control group (108.3± 36.4) (P＜0.05).The score of motor and sensory function in control group was not significantly increased at the sixth month after transplantation,while transplantation group patients got significant recovery compared with the control group (P＜0.05).The results of follow-up examination were not significantly abnormal.Conclusion The safety and recent efficacy of autologous bone marrow mesenchymal stem cells transplantation in treating early spinal cord injury by subarachnoid injection are certified.The long-term efficacy needs to be further studied.