CAJ | 학술논문

目的探讨不同类型妊娠期高血压疾病(HDIP)患者及正常妊娠产妇血清CD146水平与疾病严重程度及眼底视网膜血管病变分期的关系.方法以2010年1月至2012年1月于首都医科大学附属北京同仁医院妇产科分娩的产妇113例为研究对象,包括HDIP患者73例和正常妊娠产妇40例.HDIP患者按照疾病严重程度分为3组:妊娠期高血压组(n=22)、轻度子痫前期组(n=23)、重度子痫前期组(n=28);正常妊娠产妇为正常妊娠组(n=40).酶联免疫吸附法(ELISA)检测各组产前和产后血清CD146水平,分析CD146水平与HDIP严重程度及眼底视网膜血管病变分期的关系.结果产前、产后4组血清CD146水平差异均有统计学意义(均P＜0.05),并且随着病情加重而升高.产前轻度子痫前期组、重度子痫前期组血清CD146水平高于正常妊娠组和妊娠期高血压组(均P＜0.05).产后4组血清CD146水平均较产前下降(均P＜0.05).所有研究对象按眼底视网膜病变不同分期分为4组,产前、产后4组血清CD146水平组间比较差异均有统计学意义(均P＜0.05),并且CD146水平随眼底病变加重而升高.产前、产后眼底视网膜病变分期与HDIP严重程度之间均有显著的相关性(产前:rs=0.793,P＜0.05;产后:rs=0.631,P＜0.05).结论 CD146水平可以作为反映HDIP及眼底病变严重程度的指标.
목적 탐토불동류형임신기고혈압질병(HDIP)환자급정상임신산부혈청CD146수평여질병엄중정도급안저시망막혈관병변분기적관계.방법 이2010년1월지2012년1월우수도의과대학부속북경동인의원부산과분면적산부113례위연구대상,포괄HDIP환자73례화정상임신산부40례.HDIP환자안조질병엄중정도분위3조:임신기고혈압조(n=22)、경도자간전기조(n=23)、중도자간전기조(n=28);정상임신산부위정상임신조(n=40).매련면역흡부법(ELISA)검측각조산전화산후혈청CD146수평,분석CD146수평여HDIP엄중정도급안저시망막혈관병변분기적관계.결과 산전、산후4조혈청CD146수평차이균유통계학의의(균P＜0.05),병차수착병정가중이승고.산전경도자간전기조、중도자간전기조혈청CD146수평고우정상임신조화임신기고혈압조(균P＜0.05).산후4조혈청CD146수평균교산전하강(균P＜0.05).소유연구대상안안저시망막병변불동분기분위4조,산전、산후4조혈청CD146수평조간비교차이균유통계학의의(균P＜0.05),병차CD146수평수안저병변가중이승고.산전、산후안저시망막병변분기여HDIP엄중정도지간균유현저적상관성(산전:rs=0.793,P＜0.05;산후:rs=0.631,P＜0.05).결론 CD146수평가이작위반영HDIP급안저병변엄중정도적지표.
Objective To explore the association of severity of disease and retinal vascular lesion staging with the level of serum C D 146 from different types of hypertensive disorders in pregnancy (HDIP) patients and normal pregnancy women.Methods One hundred and thirteen cases of women giving birth from January 2010 to January 2012 in Department of Gynecology and Obstetrics,Beijing Tongren Hospital,Capital Medical University were recruited,including 73 HDIP patients and 40 normal pregnant women.HDIP patients were divided into 3 groups according to the severity of disease:gestational hypertension group (n=22),mild preeclampsia group (n=23) and severe preeclampsia group (n=28).Normal pregnant women were used as normal pregnancy group (n=40).Prenatal and postnatal serum CD146 levels in 4 groups were detected by ELISA,and the correlation between CD146 levels and HDIP severity or retinal vascular lesion staging were analyzed.Results There were significant differences in serum CD146 levels of 4 groups prenatal and postnatal (all P＜0.05),and the CD146 levels increased with the severity of disease.CD 146 expression in preeclampsia of mild,severe group was significantly higher than that in normal pregnancy group and gestational hypertension group (all P＜0.05).The C D 146 levels in postnatal of 4 groups decreased as compared to those in prenatal (all P＜0.05).All the subjects were divided into 4 groups according to different stages of retinopathy,and there were significant differences in serum CD146 levels of 4 groups prenatal or postnatal (all P＜0.05),and the levels of serum CD146 increased with the severity of retinopathy.There were significant correlations between phases of retinal lesion and the severity of HDIP during prenatal and postnatal stage (prenatal:rx=0.793,P＜0.05; postnatal:rs=0.631,P＜0.05).Conclusion CD146 level may be used as an index reflecting the severity of HDIP and retinopathy.