中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2014年
2期
146-149
,共4页
右美托咪定%芬太尼%地佐辛%胸腔热灌注
右美託咪定%芬太尼%地佐辛%胸腔熱灌註
우미탁미정%분태니%지좌신%흉강열관주
Dexmedetomidine%Fentanyl%Dezocine%Intrapleural hyperthermic perfusion
目的 观察胸腔热灌注治疗中应用右美托咪定复合地佐辛的临床效果.方法 以2013年1月至10月本院收治的全麻下行胸腔热灌注治疗的患者40例为研究对象,按随机数字表分为右美托咪定+芬太尼组(A组)和右美托咪定+地佐辛组(B组),分别于术前10 min给予芬太尼1.0 μg/kg、地佐辛0.1 mg/kg,术中均静脉持续泵注右美托咪定.记录两组患者治疗开始后5 min(T1)、15 min(T2)、30min(T3)、60 min(T4)4个时点的视觉模拟评分(VAS)及T3、T4时点的Ramsay镇静评分,记录术中不良反应的发生情况.结果 术中各时点两组患者的VAS评分差异无统计学意义(均P＞0.05).T3、T4时点,B组患者的镇静评分明显高于A组(2.45±0.61比1.50±0.55,2.78±0.75比2.45±0.92,均P＜0.05).与A组比较,B组患者不良反应发生较少.结论 右美托咪定复合地佐辛用于胸腔热灌注治疗术中镇静镇痛,效果确切,不良反应较少.
目的 觀察胸腔熱灌註治療中應用右美託咪定複閤地佐辛的臨床效果.方法 以2013年1月至10月本院收治的全痳下行胸腔熱灌註治療的患者40例為研究對象,按隨機數字錶分為右美託咪定+芬太尼組(A組)和右美託咪定+地佐辛組(B組),分彆于術前10 min給予芬太尼1.0 μg/kg、地佐辛0.1 mg/kg,術中均靜脈持續泵註右美託咪定.記錄兩組患者治療開始後5 min(T1)、15 min(T2)、30min(T3)、60 min(T4)4箇時點的視覺模擬評分(VAS)及T3、T4時點的Ramsay鎮靜評分,記錄術中不良反應的髮生情況.結果 術中各時點兩組患者的VAS評分差異無統計學意義(均P＞0.05).T3、T4時點,B組患者的鎮靜評分明顯高于A組(2.45±0.61比1.50±0.55,2.78±0.75比2.45±0.92,均P＜0.05).與A組比較,B組患者不良反應髮生較少.結論 右美託咪定複閤地佐辛用于胸腔熱灌註治療術中鎮靜鎮痛,效果確切,不良反應較少.
목적 관찰흉강열관주치료중응용우미탁미정복합지좌신적림상효과.방법 이2013년1월지10월본원수치적전마하행흉강열관주치료적환자40례위연구대상,안수궤수자표분위우미탁미정+분태니조(A조)화우미탁미정+지좌신조(B조),분별우술전10 min급여분태니1.0 μg/kg、지좌신0.1 mg/kg,술중균정맥지속빙주우미탁미정.기록량조환자치료개시후5 min(T1)、15 min(T2)、30min(T3)、60 min(T4)4개시점적시각모의평분(VAS)급T3、T4시점적Ramsay진정평분,기록술중불량반응적발생정황.결과 술중각시점량조환자적VAS평분차이무통계학의의(균P＞0.05).T3、T4시점,B조환자적진정평분명현고우A조(2.45±0.61비1.50±0.55,2.78±0.75비2.45±0.92,균P＜0.05).여A조비교,B조환자불량반응발생교소.결론 우미탁미정복합지좌신용우흉강열관주치료술중진정진통,효과학절,불량반응교소.
Objective To investigate the clinical efficacy of combined use of dexmedetomidine and dezocine in intrapleural hyperthermic perfusion.Methods Forty patients who received intrapleural hyperthermic pedusion under general anesthesia in our hospital between January and October 2013 were recruited.Based on the random digit table,the patients were randomized to receive dexmedetomidine plus 1.0 μg/kg fentanyl (group A) or plus 0.1 mg/kg dezocine (group B) at 10 min before operation.At surgery,all patients were given continuous intravenous infusion of dexmedetomidine through a pump.Visual analogue scale (VAS) scores of patients were recorded at 5 min (T1),15 rmin (T2),30 min (T3),and 60 min (T4)after start of the operation.Ramsay sedation scores were recorded at T3 and T4 time points.Occurrence of adverse reactions during operation was also recorded.Results There was no significant difference in VAS score between two groups at all time points (all P＞0.05).Sedation scores in group B was obviously higher than those in group A at T3 and T4 time points (2.45±0.61 vs 1.50±0.55,2.78±0.75 vs 2.45±0.92,both P＜0.05).Compared with group A,there were fewer adverse reactions in group B.Conclusion Combined use of dexmedetomidine and dezocine in intrapleural hyperthermic perfusion appears to be reliably efficient for intraooerative analgesics and is also with less adverse reaction.
